Mochizuki H, Tadaki H, Takami S, Muramatsu R, Hagiwara S, Mizuno T, Arakawa H
Department of Pediatrics and Developmental Medicine, Graduate School of Medicine, Gunma University, Showa-machi 3-39-15, Maebashi, Gunma 371-8511, Japan.
Br J Dermatol. 2009 May;160(5):972-9. doi: 10.1111/j.1365-2133.2009.09036.x. Epub 2009 Feb 16.
Atopic dermatitis is a disease of skin barrier dysfunction and outside stimuli can cross the skin barrier.
To examine a new method for evaluating the outside to inside skin transparency with a colorimeter and yellow dyes.
In study 1, a total of 28 volunteer subjects (24 normal and four with atopic dermatitis) participated. After provocation with yellow dye, the skin colour of all the subjects was measured using a colorimeter. The skin transparency index was calculated by the changes of the skin colour to yellow. Other variables of skin function, including transepidermal water loss (TEWL) and stratum corneum hydration, were also measured. In study 2, the skin transparency index was evaluated for a cohort of 38 patients with atopic dermatitis, 27 subjects with dry skin and 29 healthy controls.
In study 1, the measurement of skin colour (b*) using tartrazine showed good results. There was a significant relationship between the skin transparency index with tartrazine and the atopic dermatitis score (P = 0.014). No other measurements of skin function, including the TEWL, were correlated. In study 2, the skin transparency index score obtained with tartrazine in the patients with atopic dermatitis was significantly higher than that of the controls and those with dry skin (P < 0.001 and P = 0.022, respectively). However, the TEWL in patients with atopic dermatitis was not significantly higher than that of patients with dry skin and the TEWL in subjects with dry skin was not higher than that of the controls.
This method, which used a colorimeter and food dye, is noninvasive, safe and reliable for the evaluation of out-in skin transparency and can demonstrate the characteristic dysfunction in the skin barrier in patients with atopic dermatitis.
特应性皮炎是一种皮肤屏障功能障碍性疾病，外界刺激可穿透皮肤屏障。
探讨一种使用色度计和黄色染料评估皮肤由外至内透明度的新方法。
在研究1中，共有28名志愿者受试者（24名正常人及4名特应性皮炎患者）参与。用黄色染料激发后，使用色度计测量所有受试者的皮肤颜色。通过皮肤颜色向黄色的变化计算皮肤透明度指数。还测量了皮肤功能的其他变量，包括经表皮水分流失（TEWL）和角质层水合作用。在研究2中，对38名特应性皮炎患者、27名干性皮肤受试者和29名健康对照者进行了皮肤透明度指数评估。
在研究1中，使用柠檬黄测量皮肤颜色（b*）显示出良好结果。柠檬黄皮肤透明度指数与特应性皮炎评分之间存在显著相关性（P = 0.014）。未发现包括TEWL在内的其他皮肤功能测量值存在相关性。在研究2中，特应性皮炎患者使用柠檬黄获得的皮肤透明度指数评分显著高于对照组和干性皮肤受试者（分别为P < 0.001和P = 0.022）。然而，特应性皮炎患者的TEWL并不显著高于干性皮肤患者，干性皮肤受试者的TEWL也不高于对照组。
这种使用色度计和食用染料的方法对于评估皮肤由外至内的透明度是非侵入性、安全且可靠的，并且能够显示特应性皮炎患者皮肤屏障的特征性功能障碍。
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