Foresta Carlo, Selice Riccardo, Garolla Andrea, Ferlin Alberto
Department of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy.
Curr Opin Urol. 2008 Nov;18(6):602-7. doi: 10.1097/MOU.0b013e328313647d.
Treatment with gonadotrophins is very effective in patients affected by hypogonadotrophic hypogonadism. The success of follicle-stimulating hormone (FSH) treatment in these men has brought the utilization of the same therapy in infertile oligozoospermic patients, aimed at obtaining a quantitative increase in sperm count.
FSH plays a crucial role in human reproduction. This physiological role in spermatogenesis has induced various attempts to treat idiopathic oligozoospermic men with FSH, often inducing the restoration of normal spermatogenesis and spontaneous pregnancy. However, the results obtained so far are still controversial. In this research, attention is focused on the possible criteria able to predict a seminal response to the specific hormonal treatment. Moreover, we have correlated different polymorphisms of FSH receptor gene with the outcome of FSH treatment. In this article, the literature is reviewed, and the authors' experience on using FSH treatment in oligozoospermic patients is discussed.
FSH treatment may represent a valid tool for infertile men. However, it should be performed on selected patients utilizing some predictive parameters able to identify a priori responder patients with high probability.
促性腺激素治疗对性腺功能减退性性腺功能低下患者非常有效。促卵泡生成素（FSH）治疗在这些男性患者中的成功促使其在少精子症不育患者中应用，旨在使精子数量定量增加。
FSH在人类生殖中起关键作用。其在精子发生中的这一生理作用促使人们尝试用FSH治疗特发性少精子症男性，常可诱导正常精子发生的恢复及自然受孕。然而，目前所获结果仍存在争议。本研究聚焦于可能预测对特定激素治疗精液反应的标准。此外，我们将FSH受体基因的不同多态性与FSH治疗结果相关联。本文对相关文献进行综述，并讨论作者在少精子症患者中使用FSH治疗的经验。
FSH治疗可能是不育男性的有效手段。然而，应在选定患者中进行，利用一些预测参数以先验地识别高概率的反应者患者。
