Colin Ratledge Center for Microbial Lipids, School of Agriculture Engineering and Food Science, Shandong University of Technology, Zibo 255049, China.
Mayo Hospital Affiliated with King Edward Medical University, Lahore, Pakistan.
Biomed Res Int. 2018 Jul 25;2018:2070895. doi: 10.1155/2018/2070895. eCollection 2018.
The therapeutic use of natural herbs is an ancient human civilization act and the numbers of people have reliance on their pharmacological properties and preferred to use the natural herbs. People also use to consume these herbs as supplements to energize, bolster, and eventually enhance sexual ability. Polyherbal formulation (PHF) is one of these herbal amalgams that can be used to treat sexual dysfunction including erectile dysfunction, impotence, ejaculation dysfunction, and hypogonadism. The pilot study was aimed at evaluating the capacity of PHF in enhancing the spermatogenic potential of oligospermic patients. Thirty-six male patients with oligospermia were enrolled and randomized either to treatment (n = 23) with PHF (750 mg/d in three doses for 90 days) or to placebo (n = 13) in the same protocol. The preintervention semen analysis was compared with posttreatment semen analysis. Based on the postintervention semen analysis, patients were advised to undergo either fertilization (IVF) or intracytoplasmic sperm injection (ICSI) to assess their fertility status. After polyherbal treatment, there was a 256% increase in sperm concentration (9.59 ± 4.37 × 106/mL to 25.61 ± 8.6 × 10/mL; P ≤0.001), 154% increase in semen volume (1.7 ± 0.14 mL to 4.32 ± 0.38 mL; P ≤0.001), and 215% increase in sperm motility (15.43 ± 2.40% to 48.65 ± 5.10%; P ≤ 0.001) on day 90 from baseline. Furthermore, a significant improvement and regulation were also observed in serum hormone levels with PHF treatment as compared to the placebo group. The present study demonstrated the evidence on synergistic spermatogenic effect of PHF as attributed in ayurveda for the treatment of oligospermia leading to infertility.
草药的治疗用途是人类古老的文明行为，许多人依赖于其药理特性，并倾向于使用天然草药。人们也将这些草药作为补充剂来增强、提振，最终提高性能力。复方草药制剂（PHF）就是这些草药混合物之一，可用于治疗性功能障碍，包括勃起功能障碍、阳痿、射精功能障碍和性腺功能减退症。这项初步研究旨在评估 PHF 增强少精子症患者精子发生能力的能力。36 名少精子症男性患者入组并随机分为治疗组（n = 23），接受 PHF 治疗（750 mg/d，分 3 次服用，持续 90 天）或安慰剂（n = 13）治疗，采用相同方案。将干预前的精液分析与干预后的精液分析进行比较。根据干预后的精液分析结果，建议患者进行受精（IVF）或胞浆内单精子注射（ICSI），以评估其生育状况。接受复方草药治疗后，精子浓度增加了 256%（9.59 ± 4.37×106/mL 至 25.61 ± 8.6×106/mL；P ≤ 0.001），精液量增加了 154%（1.7 ± 0.14 mL 至 4.32 ± 0.38 mL；P ≤ 0.001），精子活力增加了 215%（15.43 ± 2.40%至 48.65 ± 5.10%；P ≤ 0.001），与基线相比，第 90 天。此外，与安慰剂组相比，PHF 治疗还观察到血清激素水平的显著改善和调节。本研究证明了 PHF 作为协同生精作用的证据，正如阿育吠陀中治疗少精子症导致不育症的作用一样。
