树枝状聚（L-赖氨酸）的合成与构象
Synthesis and Conformations of Dendronized Poly(L-lysine).
作者信息
Lee Cameron C, Fréchet Jean M J
机构信息
Department of Chemistry, University of California, Berkeley, California 94720-1460 and Materials Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA.
出版信息
Macromolecules. 2005 Dec 16;39(2):476-481. doi: 10.1021/ma052078b.
Abstract
Dendronized polymers based on a poly(L-lysine) backbone have been synthesized up to the fourth generation. The hydroxyl-terminated polymers are completely water-soluble, which makes them good candidates for drug delivery applications. The dendronized polypeptide backbones are helical at lower generations, but undergo a dramatic conformational change from alpha-helical to disordered upon increasing the dendron size to the third generation. This conformational change, attributed to steric repulsions between dendrons, is supported by spectroscopic measurements while chain extension upon dendronization is confirmed by scanning force microscopy.
摘要
基于聚（L-赖氨酸）主链的树枝状聚合物已合成至第四代。羟基封端的聚合物完全可溶于水，这使其成为药物递送应用的良好候选物。较低代的树枝状多肽主链呈螺旋状，但在将树枝状结构的尺寸增加到第三代时，会经历从α-螺旋到无序的剧烈构象变化。这种构象变化归因于树枝状结构之间的空间排斥，光谱测量证实了这一点，而树枝状化时的链延伸则通过扫描力显微镜得到证实。
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