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肝脏局灶性结节性增生：儿童中一种与糖尿病不常见的关联，并文献复习。

Focal nodular hyperplasia of the liver: an unusual association with diabetes mellitus in a child and review of literature.

机构信息

Unit of Pediatric Hematology and Oncology, G, Di Cristina Children's Hospital, and Department of Pediatrics, University of Palermo, Palermo, Italy.

出版信息

Ital J Pediatr. 2010 May 26;36:41. doi: 10.1186/1824-7288-36-41.

DOI:10.1186/1824-7288-36-41
PMID:20504362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2883986/
Abstract

Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood.

摘要

肝血管瘤、腺瘤和局灶性结节性增生是肝脏最常见的良性病变，但在儿童中均较为少见。儿童局灶性结节性增生的报道最近有所增加，许多病例与药物摄入有关，特别是化疗。在此，我们描述了我们所知的首例与儿童糖尿病相关的局灶性结节性增生病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af26/2883986/3dadaf4b9a0e/1824-7288-36-41-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af26/2883986/5ac4a51fd677/1824-7288-36-41-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af26/2883986/3dadaf4b9a0e/1824-7288-36-41-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af26/2883986/5ac4a51fd677/1824-7288-36-41-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/af26/2883986/3dadaf4b9a0e/1824-7288-36-41-2.jpg

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本文引用的文献

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2
The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodules.β-连环蛋白通路在局灶性结节性增生中被激活，但在肝硬化样局灶性结节性增生结节中未被激活。
J Hepatol. 2008 Jul;49(1):61-71. doi: 10.1016/j.jhep.2008.03.013. Epub 2008 Apr 18.
3
Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma.局灶性结节性增生和肝细胞腺瘤的分子发病机制。
Bone Marrow Transplant. 2015 Mar;50(3):414-9. doi: 10.1038/bmt.2014.276. Epub 2015 Jan 12.
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Comparative histomorphological review of rat and human hepatocellular proliferative lesions.大鼠与人类肝细胞增殖性病变的比较组织形态学综述
J Toxicol Pathol. 2012 Sep;25(3):189-99. doi: 10.1293/tox.25.189. Epub 2012 Oct 1.
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[Focal nodular hyperplasia in a 12-year-old boy: case report and considerations].[一名12岁男孩的局灶性结节性增生：病例报告及思考]
Pathologe. 2012 May;33(3):254-61. doi: 10.1007/s00292-012-1567-y.
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A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia.一项基因表达定量研究表明血管生成素在局灶性结节性增生中起作用。
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