Ellis J M, Folkers K, Minadeo M, VanBuskirk R, Xia L J, Tamagawa H
Department of Medicine, Titus County Hospital, Mt. Pleasant, Texas.
Biochem Biophys Res Commun. 1991 Aug 30;179(1):615-9. doi: 10.1016/0006-291x(91)91416-a.
Eighteen patients with diabetes mellitus, some of whom had variously retinopathy, pregnancy, and the carpal tunnel syndrome, and were variously treated with steroids and vitamin B6, have been overviewed for periods of 8 months to 28 years. We have established an association of a deficiency of vitamin B6 with diabetes by monitoring the specific activity of the erythrocyte glutamic oxaloacetic transaminase and again by the association with the carpal tunnel syndrome (C.T.S.). It has been known for a decade that C.T.S. is caused by a B6 deficiency. The absence of retinopathy in vitamin B6-treated diabetic patients over periods of 8 months - 28 years appears monumental. These observations are like discovery and constitute a basis for a new protocol to establish the apparent relationship of a deficiency of vitamin B6 as a molecular cause of diabetic neuropathy. Blindness and vision are so important that the strength or weakness of the observations are not important; the conduct of a new protocol is important.
18例糖尿病患者，其中部分患者患有不同程度的视网膜病变、妊娠及腕管综合征，并接受了不同的类固醇和维生素B6治疗，观察时间为8个月至28年。我们通过监测红细胞谷草转氨酶的比活性，以及再次通过与腕管综合征（C.T.S.）的关联，确定了维生素B6缺乏与糖尿病之间的关联。十年来一直已知腕管综合征是由维生素B6缺乏引起的。在接受维生素B6治疗的糖尿病患者中，长达8个月至28年未出现视网膜病变，这一现象显得意义重大。这些观察结果宛如一项发现，为建立维生素B6缺乏作为糖尿病神经病变分子病因的明显关系的新方案奠定了基础。失明和视力至关重要，以至于观察结果的强弱并不重要；开展新方案才是重要的。
