Babu P S, Srinivasan K
Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India.
Mol Cell Biochem. 1997 Oct;175(1-2):49-57. doi: 10.1023/a:1006881027166.
Effect of feeding 15 mg% capsaicin diet or 3% freeze dried onion powder containing diet were examined in albino rats rendered diabetic with streptozotocin injection. Diabetic rats maintained on onion diet for 8 weeks excreted comparatively less amounts of albumin, urea, creatinine and inorganic phosphorus. Dietary onion also partially reversed the abnormalities in plasma albumin, urea, creatinine and inorganic phosphorus in diabetic animals. Onion also produced a significant reduction in hyperglycemic status of diabetic animals. Diabetic rats maintained on onion diet had a lowered relative liver weight at the end of the study compared to diabetic control group. Diabetic rats fed onion diet also exhibited lowered lipid peroxides in circulation and in urine when compared to diabetic control group. Blood cholesterol was lowered significantly by dietary onion in diabetic animals. Cholesterol decrease was exclusively from LDL-VLDL fraction. Significant decrease in blood phospholipids and triglycerides also brought about by dietary onion. Hepatic cholesterol, triglycerides, phospholipids which were elevated under diabetic condition were countered significantly by dietary onion. Dietary capsaicin did not have any significant influence on any of the parameters tested in diabetic rats. Thus, the study reveals that onion feeding improves the metabolic status in diabetic condition, probably because of its hypoglycemic as well as hypocholesterolemic effect.
在通过注射链脲佐菌素诱导糖尿病的白化病大鼠中，研究了喂食含15毫克%辣椒素的饮食或含3%冻干洋葱粉的饮食的效果。糖尿病大鼠食用洋葱饮食8周后，白蛋白、尿素、肌酐和无机磷的排泄量相对较少。饮食中的洋葱还部分逆转了糖尿病动物血浆白蛋白、尿素、肌酐和无机磷的异常。洋葱还显著降低了糖尿病动物的高血糖状态。与糖尿病对照组相比，在研究结束时，食用洋葱饮食的糖尿病大鼠肝脏相对重量降低。与糖尿病对照组相比，食用洋葱饮食的糖尿病大鼠循环和尿液中的脂质过氧化物也有所降低。饮食中的洋葱显著降低了糖尿病动物的血液胆固醇。胆固醇的降低仅来自低密度脂蛋白-极低密度脂蛋白部分。饮食中的洋葱还显著降低了血液中的磷脂和甘油三酯。糖尿病状态下升高的肝脏胆固醇、甘油三酯和磷脂被饮食中的洋葱显著抵消。饮食中的辣椒素对糖尿病大鼠测试的任何参数均无显著影响。因此，该研究表明，喂食洋葱可改善糖尿病状态下的代谢状况，这可能是由于其降血糖以及降胆固醇的作用。
