Chheda Neil N, Postma Gregory N
Department of Otolaryngology, Medical College of Georgia, Augusta, Georgia 30912, USA.
Ann Otol Rhinol Laryngol. 2008 Sep;117(9):670-2. doi: 10.1177/000348940811700907.
Proton pump inhibitors (PPIs) are used for the treatment of numerous otolaryngological disorders. It has been demonstrated that administration of the medication 15 to 45 minutes before a meal optimizes acid suppression. The rate of compliance with optimal PPI dosage patterns in an otolaryngology practice is not known. We sought to determine the rate of PPI compliance in patients seen in an otolaryngology practice.
We conducted an interview at a tertiary voice and swallowing center of 200 consecutive patients who were taking PPIs.
Overall, 54% of patients took their PPI in an optimal manner. The rate of compliance was significantly higher for patients who had their PPI prescribed by an otolaryngologist (62%) than for patients whose PPI was prescribed by a non-otolaryngologist (40%).
Nearly half of all patients seen at a voice and swallowing center were not compliant with optimal PPI usage. This percentage is similar to that found for other long-term medications. Patient education can lead to higher rates of compliance, improved acid control, and possibly improved treatment outcomes.
质子泵抑制剂（PPIs）用于治疗多种耳鼻喉科疾病。已证实，在餐前15至45分钟服用该药物可优化胃酸抑制效果。在耳鼻喉科实践中，患者对最佳质子泵抑制剂剂量模式的依从率尚不清楚。我们试图确定在耳鼻喉科实践中就诊的患者使用质子泵抑制剂的依从率。
我们在一家三级嗓音与吞咽中心对200名连续服用质子泵抑制剂的患者进行了访谈。
总体而言，54%的患者以最佳方式服用质子泵抑制剂。由耳鼻喉科医生开具质子泵抑制剂处方的患者依从率（62%）显著高于由非耳鼻喉科医生开具处方的患者（40%）。
在嗓音与吞咽中心就诊的所有患者中，近一半未遵循最佳质子泵抑制剂使用方法。这一比例与其他长期用药的情况相似。患者教育可提高依从率、改善胃酸控制，并可能改善治疗效果。
