Lacroix-Fralish Michael L, Mogil Jeffrey S
Department of Psychology and Center for Research on Pain, McGill University, Montréal, Quebec, H3A1B1 Canada.
Annu Rev Pharmacol Toxicol. 2009;49:97-121. doi: 10.1146/annurev-pharmtox-061008-103222.
Interindividual variability in pain sensitivity and the response to analgesic manipulations remains a considerable clinical challenge as well as an area of intense scientific investigation. Techniques in this field have matured rapidly so that much relevant data have emerged only in the past few years. Our increasing understanding of the genetic mediation of these biological phenomena have nonetheless revealed their surprising complexity. This review provides a comprehensive picture and critical analysis of the field and its prospects.
个体间疼痛敏感性及对镇痛措施反应的差异，仍然是一项重大的临床挑战，也是一个深入科学研究的领域。该领域的技术发展迅速，以至于许多相关数据仅在过去几年才出现。然而，我们对这些生物学现象的遗传介导的日益了解，揭示了它们惊人的复杂性。本综述全面介绍并批判性分析了该领域及其前景。
