一些新型螺吡喃香豆素的合成及自由基清除活性
Synthesis and free radical scavenging activity of some new spiropyranocoumarins.
作者信息
Panteleon Vassiliki, Kostakis Ioannis K, Marakos Panagiotis, Pouli Nicole, Andreadou Ioanna
机构信息
Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
出版信息
Bioorg Med Chem Lett. 2008 Nov 1;18(21):5781-4. doi: 10.1016/j.bmcl.2008.09.065. Epub 2008 Sep 20.
PMID:18835711
Abstract
A series of novel spiro-substituted 4-hydroxypyranocoumarins and their corresponding dihydropyrano cis-diols has been synthesized. Among them the spiroadamantylpyranocoumarin and the diols can interact with the stable free radical 1,1-diphenyl-2-picrylhydrazyl and scavenge superoxide anions generated in the xanthine-xanthine oxidase system.
摘要
一系列新型的螺环取代的4-羟基吡喃香豆素及其相应的二氢吡喃顺式二醇已被合成。其中，螺金刚烷基吡喃香豆素和二醇可与稳定自由基1,1-二苯基-2-苦基肼相互作用，并清除黄嘌呤-黄嘌呤氧化酶系统中产生的超氧阴离子。
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