Synthesis of some new spiropyranoquinolines and evaluation of their free radical scavenging activity.
作者信息
Panteleon Vassiliki, Kostakis Ioannis K, Marakos Panagiotis, Pouli Nicole, Andreadou Ioanna
机构信息
Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Athens, Greece.
出版信息
Chem Pharm Bull (Tokyo). 2009 May;57(5):446-52. doi: 10.1248/cpb.57.446.
PMID:19420773
Abstract
The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine-xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.
摘要
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