从一种海虾中分离出的具有降低抗凝活性的类肝素糖胺聚糖的抗炎特性
Anti-inflammatory properties of a heparin-like glycosaminoglycan with reduced anti-coagulant activity isolated from a marine shrimp.
作者信息
Brito Adriana S, Arimatéia Dayse S, Souza Lucilla R, Lima Marcelo A, Santos Vanessa O, Medeiros Valquíria P, Ferreira Paula A, Silva Rodrigo A, Ferreira Carmen V, Justo Giselle Z, Leite Edda L, Andrade Giulianna P V, Oliveira Fernanda W, Nader Helena B, Chavante Suely F
机构信息
Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, UFRN, Campus Universitario, Natal, RN, Brazil.
出版信息
Bioorg Med Chem. 2008 Nov 1;16(21):9588-95. doi: 10.1016/j.bmc.2008.09.020. Epub 2008 Sep 12.
The anti-inflammatory properties of a heparin-like compound from the shrimp Litopenaeus vannamei are related. Besides reducing significantly (p<0.001) the influx of inflammatory cells to injury site in a model of acute inflammation, shrimp heparin-like compound was able to reduce the matrix metalloproteinase (MMPs) activity in the peritoneal lavage of inflamed animals. Moreover, this compound also reduced almost 90% the activity of MMP-9 secreted by human activated leukocytes. Negligible anti-coagulant activities in aPPT assay and a poor bleeding potential make this compound a better alternative than mammalian heparin as a possible anti-inflammatory drug.
凡纳滨对虾中一种类肝素化合物的抗炎特性与之相关。除了在急性炎症模型中显著（p<0.001）减少炎症细胞向损伤部位的流入外，虾类肝素化合物还能够降低炎症动物腹腔灌洗液中基质金属蛋白酶（MMPs）的活性。此外，该化合物还使人类活化白细胞分泌的MMP-9活性降低了近90%。在活化部分凝血活酶时间（aPPT）测定中可忽略不计的抗凝血活性以及较差的出血可能性，使得该化合物成为比哺乳动物肝素更好的潜在抗炎药物替代品。
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