Rendina Domenico, Mossetti Giuseppe, De Filippo Gianpaolo, Benvenuto Domenico, Vivona Carmen Liliana, Imbroinise Alessia, Zampa Giorgia, Ricchio Salvatore, Strazzullo Pasquale
Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy.
Nephrol Dial Transplant. 2009 Mar;24(3):900-6. doi: 10.1093/ndt/gfn548. Epub 2008 Oct 3.
Metabolic syndrome (MetS) and nephrolithiasis (NL) are quite common disorders. While some of the components of MetS have been proposed as precursors of NL in population studies, no data are available about the possible association between NL and MetS as such. The primary objective of the study was to evaluate the relationship between MetS and NL. The secondary outcome was to examine the relationship between MetS single constitutive elements and NL considering the strict correlation occurring among these factors.
We studied 2132 Caucasian inpatients of the 'Spinelli' Hospital in southern Italy (males/females = 0.95; mean age 63.8 +/- 15.8 years; body mass index 26.1 +/- 3.9 kg/m(2)). The MetS diagnosis was performed according to the Heart Association/National Heart, Lung, and Blood Institute criteria. The presence of NL was assessed by ultrasound examination of the kidneys and upper urinary tract.
Seven hundred twenty-five subjects (34.0%) had a positive diagnosis of MetS. Two hundred twenty subjects (10.3%) had echographic evidence of NL, while 199 subjects reported a past history of NL (9.3%). The presence of MetS, as well as the male sex, and the occurrence of a previous episode of NL (in male subjects only) were each independently related to echographic evidence of NL. Among the individual components of MetS, high blood pressure and abdominal obesity (in female individuals only) were also independently related to echographic evidence of NL.
MetS is significantly associated with echographic evidence of NL. A gender-related difference in the clinical expression of NL was also observed.
代谢综合征（MetS）和肾结石（NL）是相当常见的病症。虽然在人群研究中已提出MetS的一些组成部分是NL的先兆，但尚无关于NL与MetS之间可能关联的数据。本研究的主要目的是评估MetS与NL之间的关系。次要结果是考虑到这些因素之间存在的严格相关性，研究MetS的各个构成要素与NL之间的关系。
我们研究了意大利南部“斯皮内利”医院的2132名白种人住院患者（男性/女性=0.95；平均年龄63.8±15.8岁；体重指数26.1±3.9kg/m²）。根据美国心脏协会/美国国立心肺血液研究所的标准进行MetS诊断。通过肾脏和上尿路的超声检查评估NL的存在情况。
725名受试者（34.0%）MetS诊断呈阳性。220名受试者（10.3%）有NL的超声证据，而199名受试者报告有NL病史（9.3%）。MetS的存在、男性性别以及既往有NL发作史（仅男性受试者）均与NL的超声证据独立相关。在MetS的各个组成部分中，高血压和腹部肥胖（仅女性个体）也与NL的超声证据独立相关。
MetS与NL的超声证据显著相关。还观察到NL临床表现存在性别差异。
