Chapidze Gulnara, Dolidze Nino, Enquobahrie Daniel A, Kapanadze Simon, Latsabidze Nino, Williams Michelle A
Emergency Cardiology Center, Tbilisi, Republic of Georgia.
Arch Med Res. 2007 Oct;38(7):783-8. doi: 10.1016/j.arcmed.2007.03.011. Epub 2007 Jun 21.
Associations between inflammation, metabolic syndrome (MetS), and cardiovascular disease have been reported. Limited information, however, is available on the prevalence of MetS and its relation to inflammation among Georgian cardiology patients. We investigated MetS components (elevated blood pressure, abdominal obesity, elevated triglyceride concentrations, decreased HDL-cholesterol concentrations, and elevated fasting glucose) and their relationships with C-reactive protein (CRP) concentrations in this population.
A total of 167 patients (mean age 53.1 years, 54% male) who attended an Emergency Cardiology Center in Tbilisi, Republic of Georgia were enrolled in this cross-sectional study. In-person interviews and clinical exams, as well as laboratory studies, were conducted to characterize MetS (using the ATP III criteria) and cardiac conditions in the study population. CRP concentrations were determined using standardized immunoassays.
Overall prevalence of MetS was 40.7%. Patients with coronary heart disease (CHD) had higher CRP concentrations compared with non-CHD patients. A linear relationship between increase in number of MetS components and CRP concentrations was observed among females (p value for linear trend <0.05), but not males. Further, among females, all components of MetS except HDL-C concentrations were correlated with CRP concentrations after adjustment for age and body mass index (all p values <0.05). However, among males, only abdominal obesity was significantly correlated with CRP.
MetS is prevalent among Georgian cardiology patients. CRP concentrations are positively associated with MetS. Further prospective studies are required to determine whether combining MetS and CRP data may have utility in the assessment of risk for developing future cardiovascular events in both males and females.
炎症、代谢综合征（MetS）与心血管疾病之间的关联已有报道。然而，关于格鲁吉亚心脏病患者中MetS的患病率及其与炎症的关系，现有信息有限。我们在这一人群中调查了MetS的组成部分（血压升高、腹型肥胖、甘油三酯浓度升高、高密度脂蛋白胆固醇浓度降低和空腹血糖升高）及其与C反应蛋白（CRP）浓度的关系。
总共167名患者（平均年龄53.1岁，54%为男性）参与了这项横断面研究，他们均前往格鲁吉亚共和国第比利斯的一家急诊心脏病中心就诊。通过面对面访谈、临床检查以及实验室研究，对研究人群中的MetS（采用ATP III标准）和心脏状况进行了评估。使用标准化免疫测定法测定CRP浓度。
MetS的总体患病率为40.7%。冠心病（CHD）患者的CRP浓度高于非CHD患者。在女性中观察到MetS组成部分数量增加与CRP浓度之间存在线性关系（线性趋势的p值<0.05），但男性中未观察到。此外，在女性中，调整年龄和体重指数后，除高密度脂蛋白胆固醇浓度外，MetS的所有组成部分均与CRP浓度相关（所有p值<0.05）。然而，在男性中，只有腹型肥胖与CRP显著相关。
MetS在格鲁吉亚心脏病患者中普遍存在。CRP浓度与MetS呈正相关。需要进一步的前瞻性研究来确定结合MetS和CRP数据是否有助于评估男性和女性未来发生心血管事件的风险。
