Molecular Oncology Programme, Spanish National Cancer Centre (CNIO), Madrid 28034, Spain.
Cell Rep. 2012 Sep 27;2(3):526-39. doi: 10.1016/j.celrep.2012.08.012. Epub 2012 Sep 13.
Cell competition is a mechanism that eliminates slow dividing cells from a growing population. It is believed that the genes wasp, psr, and draper are active in the cells that win the competition ("winner cells") and that they are essential in the winner cells for the induction of apoptosis and for the elimination of the "loser cells." Here, we show that lack of those genes in winner cells appears to be dispensable for cell-competition-induced apoptosis and during dmyc-induced supercompetition. Moreover, winner clones do not need those genes in order to preserve their growth advantage. Finally, we find that most of the clearance of the apoptotic debris is not performed by winners but by recruited hemocytes, which are required for the removal of the apoptotic corpses at the very end. Therefore, engulfment is a consequence-not a cause-of loser cells' death.
细胞竞争是一种从生长群体中淘汰缓慢分裂细胞的机制。人们认为基因 wasp、psr 和 draper 在赢得竞争的细胞（“获胜细胞”）中活跃，并且它们对于诱导细胞凋亡和消除“失败细胞”是必不可少的。在这里，我们表明，在细胞竞争诱导的细胞凋亡和 dmyc 诱导的超竞争期间，缺乏这些基因似乎对获胜细胞是可有可无的。此外，获胜克隆不需要这些基因来维持它们的生长优势。最后，我们发现大多数凋亡碎片的清除不是由获胜者完成的，而是由招募的血细胞完成的，在最后阶段需要血细胞来清除凋亡尸体。因此，吞噬作用是失败者死亡的结果，而不是原因。
