Directed hybridization of DNA derivatized nanoparticles into higher order structures.

作者信息

Dehlinger Dietrich A, Sullivan Benjamin D, Esener Sadik, Heller Michael J

机构信息

Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, California 92093-0412, USA.

出版信息

Nano Lett. 2008 Nov;8(11):4053-60. doi: 10.1021/nl802369b. Epub 2008 Oct 7.

DOI:10.1021/nl802369b

PMID:18837562

Abstract

Electric field directed hybridization was used to produce twenty layer nanostructures composed of DNA derivatized nanoparticles. Using an electronic microarray device, DNA nanoparticles could be directed and concentrated such that rapid and specific hybridization occurs only on the activated sites. Nanoparticle layers were formed within 30 s of activation and twenty layer structures completed in under an hour. Results demonstrate a unique combination of bottom-up and top-down techniques for nanofabrication.

摘要