Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, 256 Grays Inn Road, London WC1X 8LD, UK.
Biomaterials. 2009 Jan;30(1):89-93. doi: 10.1016/j.biomaterials.2008.09.020. Epub 2008 Oct 5.
We report the formation of polysiloxane polymers containing embedded methylene blue and gold nanoparticles incorporated by a swell-encapsulation-shrink method. These polymers show significant antimicrobial activity against methicillin-resistant Staphylococcus aureus and Escherichia coli with up to a 3.5 log(10) reduction in the viable count when exposed for 5 min to light from a low power 660 nm laser. The bacterial kill is due to the light-induced production of singlet oxygen and other reactive oxygen species by the methylene blue. Interestingly, the presence of 2 nm gold nanoparticles significantly enhanced the ability of the methylene blue to kill bacteria.
我们报告了一种通过溶胀-包封-收缩方法形成的含有嵌入亚甲蓝和金纳米粒子的聚硅氧烷聚合物。这些聚合物在暴露于低功率 660nm 激光 5 分钟时，对耐甲氧西林金黄色葡萄球菌和大肠杆菌表现出显著的抗菌活性，活菌数减少了 3.5log(10)。细菌的杀灭是由于亚甲蓝产生的单线态氧和其他活性氧物质的光诱导。有趣的是，2nm 金纳米粒子的存在显著提高了亚甲蓝杀死细菌的能力。
