• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于有效光动力灭活病毒的碳点

Carbon dots for effective photodynamic inactivation of virus.

作者信息

Dong Xiuli, Edmondson Rasheena, Yang Fan, Tang Yongan, Wang Ping, Sun Ya-Ping, Yang Liju

机构信息

Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise (BRITE), North Carolina Central University Durham NC 27707 USA

Department of Biology, Bennett College Greensboro NC 27401 USA.

出版信息

RSC Adv. 2020 Sep 14;10(56):33944-33954. doi: 10.1039/d0ra05849a. eCollection 2020 Sep 10.

DOI:10.1039/d0ra05849a
PMID:35519058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9056736/
Abstract

The antiviral function of carbon dots (CDots) with visible light exposure was evaluated, for which the model bacteriophages MS2 as a surrogate of small RNA viruses were used. The results show clearly that the visible light-activated CDots are highly effective in diminishing the infectivity of MS2 in both low and high titer samples to the host cells, and the antiviral effects are dot concentration- and treatment time-dependent. The action of CDots apparently causes no significant damage to the structural integrity and morphology of the MS2 phage or the breakdown of the capsid proteins, but does result in the protein carbonylation (a commonly used indicator for protein oxidation) and the degradation of viral genomic RNA. Mechanistically the results may be understood in the framework of photodynamic effects that are associated with the unique excited state properties and processes of CDots. Opportunities for potentially broad applications of CDots coupled with visible/natural light in the prevention and control of viral transmission and spread are highlighted and discussed.

摘要

评估了可见光照射下碳点（CDots）的抗病毒功能，为此使用了模型噬菌体MS2作为小RNA病毒的替代物。结果清楚地表明，可见光激活的碳点在降低低滴度和高滴度样品中MS2对宿主细胞的感染性方面非常有效，并且抗病毒效果取决于碳点浓度和处理时间。碳点的作用显然不会对MS2噬菌体的结构完整性和形态造成显著损害，也不会导致衣壳蛋白的分解，但会导致蛋白质羰基化（蛋白质氧化的常用指标）和病毒基因组RNA的降解。从机制上讲，这些结果可以在与碳点独特的激发态性质和过程相关的光动力效应框架内得到理解。强调并讨论了碳点与可见光/自然光结合在预防和控制病毒传播方面潜在广泛应用的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/34b4b2a16b2d/d0ra05849a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/908d0cb425e2/d0ra05849a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/ab1e4ee65169/d0ra05849a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/fe5f62880b5c/d0ra05849a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/535d1c3b5996/d0ra05849a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/57e415435d42/d0ra05849a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/846b4e4c856d/d0ra05849a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/34b4b2a16b2d/d0ra05849a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/908d0cb425e2/d0ra05849a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/ab1e4ee65169/d0ra05849a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/fe5f62880b5c/d0ra05849a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/535d1c3b5996/d0ra05849a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/57e415435d42/d0ra05849a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/846b4e4c856d/d0ra05849a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/afaf/9056736/34b4b2a16b2d/d0ra05849a-f7.jpg

相似文献

1
Carbon dots for effective photodynamic inactivation of virus.用于有效光动力灭活病毒的碳点
RSC Adv. 2020 Sep 14;10(56):33944-33954. doi: 10.1039/d0ra05849a. eCollection 2020 Sep 10.
2
Inactivation of Vesicular Stomatitis Virus with Light-Activated Carbon Dots and Mechanistic Implications.用光激活的碳点灭活水疱性口炎病毒及其机制研究。
ACS Appl Bio Mater. 2022 Jul 18;5(7):3158-3166. doi: 10.1021/acsabm.2c00153. Epub 2022 Jul 7.
3
Visible Light-Activated Carbon Dots for Inhibiting Biofilm Formation and Inactivating Biofilm-Associated Bacterial Cells.用于抑制生物膜形成和使生物膜相关细菌细胞失活的可见光激活碳点
Front Bioeng Biotechnol. 2021 Nov 18;9:786077. doi: 10.3389/fbioe.2021.786077. eCollection 2021.
4
Carbon Dots' Antiviral Functions Against Noroviruses.碳点对诺如病毒的抗病毒功能。
Sci Rep. 2017 Mar 31;7(1):519. doi: 10.1038/s41598-017-00675-x.
5
Carbon Dots as Potent Antimicrobial Agents.碳点作为有效的抗菌剂。
Theranostics. 2020 Jan 1;10(2):671-686. doi: 10.7150/thno.39863. eCollection 2020.
6
The dominant role of surface functionalization in carbon dots' photo-activated antibacterial activity.表面功能化在碳点光激活抗菌活性中的主导作用。
Int J Nanomedicine. 2019 Apr 23;14:2655-2665. doi: 10.2147/IJN.S200493. eCollection 2019.
7
Photoactivated Carbon Dots for Inactivation of Foodborne Pathogens and Salmonella.光活化碳点用于灭活食源性病原体和沙门氏菌。
Appl Environ Microbiol. 2021 Nov 10;87(23):e0104221. doi: 10.1128/AEM.01042-21. Epub 2021 Sep 22.
8
Photodynamic inactivation of bacteriophage MS2: The A-protein is the target of virus inactivation.噬菌体MS2的光动力失活：A蛋白是病毒失活的靶点。
J Photochem Photobiol B. 2018 Jan;178:404-411. doi: 10.1016/j.jphotobiol.2017.11.032. Epub 2017 Nov 26.
9
Near-infrared emitting dual-stimuli-responsive carbon dots from endogenous bile pigments.源自内源性胆汁色素的近红外发射双刺激响应碳点
Nanoscale. 2021 Aug 21;13(31):13487-13496. doi: 10.1039/d1nr01295a. Epub 2021 Jul 30.
10
Visible-Light-Activated Bactericidal Functions of Carbon "Quantum" Dots.碳“量子”点的可见光激活杀菌功能
ACS Appl Mater Interfaces. 2016 May 4;8(17):10761-6. doi: 10.1021/acsami.6b01765. Epub 2016 Apr 22.

引用本文的文献

1
An Overview of Diverse Strategies To Inactivate -Targeting Bacteriophages.靶向噬菌体的多种灭活策略概述
EcoSal Plus. 2023 Dec 12;11(1):eesp00192022. doi: 10.1128/ecosalplus.esp-0019-2022. Epub 2023 Jan 18.
2
Progress on Applying Carbon Dots for Inhibition of RNA Virus Infection.用于抑制 RNA 病毒感染的碳点应用进展。
Nanotheranostics. 2022 Aug 21;6(4):436-450. doi: 10.7150/ntno.73918. eCollection 2022.
3
Rational design of large flat nitrogen-doped graphene oxide quantum dots with green-luminescence suitable for biomedical applications.

本文引用的文献

1
Selective Naked-Eye Detection of SARS-CoV-2 Mediated by N Gene Targeted Antisense Oligonucleotide Capped Plasmonic Nanoparticles.基于靶向 N 基因的反义寡核苷酸修饰的等离子体纳米粒子的 SARS-CoV-2 选择性裸眼检测。
ACS Nano. 2020 Jun 23;14(6):7617-7627. doi: 10.1021/acsnano.0c03822. Epub 2020 May 28.
2
Carbon "quantum" dots for optical bioimaging.用于光学生物成像的碳“量子”点。
J Mater Chem B. 2013 Apr 28;1(16):2116-2127. doi: 10.1039/c3tb00018d. Epub 2013 Mar 11.
3
Carbon Dots as Potent Antimicrobial Agents.碳点作为有效的抗菌剂。
适用于生物医学应用的具有绿色发光特性的大尺寸扁平氮掺杂氧化石墨烯量子点的合理设计。
RSC Adv. 2022 May 12;12(23):14342-14355. doi: 10.1039/d2ra01516a.
4
Carbon "quantum" dots for bioapplications.用于生物应用的碳“量子”点。
Exp Biol Med (Maywood). 2022 Feb;247(4):300-309. doi: 10.1177/15353702211057513. Epub 2021 Dec 3.
5
Carbon dots for virus detection and therapy.用于病毒检测和治疗的碳点。
Mikrochim Acta. 2021 Nov 25;188(12):430. doi: 10.1007/s00604-021-05076-6.
Theranostics. 2020 Jan 1;10(2):671-686. doi: 10.7150/thno.39863. eCollection 2020.
4
The dominant role of surface functionalization in carbon dots' photo-activated antibacterial activity.表面功能化在碳点光激活抗菌活性中的主导作用。
Int J Nanomedicine. 2019 Apr 23;14:2655-2665. doi: 10.2147/IJN.S200493. eCollection 2019.
5
A combinatorial approach of structure-based virtual screening and molecular dynamics simulation towards the discovery of a highly selective inhibitor for VP9 coat protein of Banna virus.基于结构的虚拟筛选和分子动力学模拟的组合方法，用于发现一种对 Banna 病毒 VP9 外壳蛋白具有高选择性的抑制剂。
Bioorg Chem. 2019 May;86:15-27. doi: 10.1016/j.bioorg.2019.01.021. Epub 2019 Jan 12.
6
Synergistic photoactivated antimicrobial effects of carbon dots combined with dye photosensitizers.碳点与染料光敏剂协同的光激活抗菌作用。
Int J Nanomedicine. 2018 Nov 27;13:8025-8035. doi: 10.2147/IJN.S183086. eCollection 2018.
7
Systematic Toxicity Evaluations of High-Performance Carbon "Quantum" Dots.高通量碳“量子”点的系统毒性评估。
J Nanosci Nanotechnol. 2019 Apr 1;19(4):2130-2137. doi: 10.1166/jnn.2019.15807.
8
RNA Phage Biology in a Metagenomic Era.宏基因组时代的 RNA 噬菌体生物学
Viruses. 2018 Jul 21;10(7):386. doi: 10.3390/v10070386.
9
Photodynamic inactivation of bacteriophage MS2: The A-protein is the target of virus inactivation.噬菌体MS2的光动力失活：A蛋白是病毒失活的靶点。
J Photochem Photobiol B. 2018 Jan;178:404-411. doi: 10.1016/j.jphotobiol.2017.11.032. Epub 2017 Nov 26.
10
Correlation of Carbon Dots' Light-Activated Antimicrobial Activities and Fluorescence Quantum Yield.碳点的光激活抗菌活性与荧光量子产率的相关性
RSC Adv. 2017;7(48):30177-30184. doi: 10.1039/C7RA05397E. Epub 2017 Jun 12.