Novgorodov S A, Gudz' T I, Zorov D B, Kushnareva Iu E, Kudriashov Iu B
Biokhimiia. 1991 Mar;56(3):529-35.
The effect of oligomycin and cyclosporine A on Ca(2+)-induced nonspecific permeability of the inner mitochondrial membrane was under study. Both oligomycin and cyclosporine A were able to prevent the activation of nonspecific permeability; however, but cyclosporine A was the only agent which could restore the initial permeability of the inner mitochondrial membrane. The effect of cyclosporine A was not shown to be mediated through redistribution of Ca2+ ions between different subpopulations of mitochondria.
正在研究寡霉素和环孢素A对钙离子诱导的线粒体内膜非特异性通透性的影响。寡霉素和环孢素A都能够阻止非特异性通透性的激活；然而，环孢素A是唯一能够恢复线粒体内膜初始通透性的药物。未发现环孢素A的作用是通过钙离子在线粒体不同亚群之间的重新分布介导的。
