Cintra A, Solfrini V, Agnati L F, Gustafsson J A, Fuxe K
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden.
Neuroreport. 1991 Feb;2(2):85-8. doi: 10.1097/00001756-199102000-00005.
Brain glucocorticoid receptor (GR) immunoreactivity was studied in the neonatal rat. Already at postnatal days 1-3 strongly GR immunoreactive (IR) neurons were found in the arcuate and paraventricular hypothalamic nuclei. Moderately to strongly GR IR neurons were found in the locus coeruleus and raphe nuclei, while only weakly GR IR neurons were present in the CA1 and CA2 areas of the hippocampus. GR IR increases steadily during the postnatal period reaching adult levels at day 16. Thus, GR may play a role in the maturation of these hypothalamic nuclei and the 5-hydroxytryptamine and noradrenaline neurons, and GR may provide a basis for the ability of stress-induced increases of glucocorticoids to influence distinct brain circuits during postnatal development.
在新生大鼠中研究了脑糖皮质激素受体（GR）免疫反应性。在出生后1 - 3天，已在弓状核和下丘脑室旁核中发现强GR免疫反应性（IR）神经元。在蓝斑核和中缝核中发现中度至强GR IR神经元，而在海马体的CA1和CA2区域仅存在弱GR IR神经元。GR IR在出生后时期稳步增加，在第16天达到成年水平。因此，GR可能在这些下丘脑核以及5 - 羟色胺和去甲肾上腺素能神经元的成熟中发挥作用，并且GR可能为应激诱导的糖皮质激素增加在出生后发育过程中影响不同脑回路的能力提供基础。
