Martins Andrew, Lautens Mark
Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario, Canada M5S 3H6.
Org Lett. 2008 Nov 6;10(21):5095-7. doi: 10.1021/ol802185x. Epub 2008 Oct 8.
The discovery of a novel arylpalladium(II) reduction enables the synthesis of diarylmethanes via reductive benzylation. Benzyl chlorides were found to be the major source of hydride, acting as an alkylating agent and an aprotic surrogate for benzyl alcohol. This represents the first example of an arylpalladium(II) reduction mediated by a benzyl halide.
一种新型芳基钯（II）还原反应的发现使得通过还原苄基化反应合成二芳基甲烷成为可能。发现苄基氯是氢化物的主要来源，它作为烷基化剂和苄醇的非质子替代物。这代表了由苄基卤介导的芳基钯（II）还原反应的首个实例。
