Martorell Miguel, Gaona Morales John Jairo, Garcia Jose Angel, Manuel Gutierrez Herrera Jair, Grau Francisco Gozalbo, Calabuig Consuelo, Vallés Ana Pérez
Department of Pathology, Consorcio Hospital General University of Valencia, Medical School, University of Valencia, Valencia, Spain.
J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):699-705. doi: 10.1111/j.1447-0756.2008.00910.x.
Lymphomas arising in the female genital tract are extremely uncommon. Diffuse large B-cell lymphoma and follicular lymphoma are the most common types. We describe the case of an 80-year-old woman with a recurrent lesion in the vulva initially diagnosed as a lymphoma-like lesion and evolving 7 years later into a marginal zone B-cell lymphoma (lymphoplasmacytic lymphoma). Diagnosis was based on the monotypic pattern of the plasmacellular component and the clonal rearrangement of immunoglobulin heavy chain genes. No previous cases of vulvar marginal zone B-cell lymphoma arising in the context of a persistent lymphoma-like lesion have been reported. We highlight the importance of differentiating benign from malignant lymphoid infiltrates in the vulva.
发生于女性生殖道的淋巴瘤极为罕见。弥漫性大B细胞淋巴瘤和滤泡性淋巴瘤是最常见的类型。我们报告一例80岁女性，其外阴部有复发性病变，最初诊断为淋巴瘤样病变，7年后演变为边缘区B细胞淋巴瘤（淋巴浆细胞性淋巴瘤）。诊断基于浆细胞成分的单型模式以及免疫球蛋白重链基因的克隆性重排。此前尚无在持续性淋巴瘤样病变背景下发生外阴边缘区B细胞淋巴瘤的病例报道。我们强调了区分外阴部良性与恶性淋巴样浸润的重要性。
