Sahu Latika, Bupathy A, Badhe Bhavana A
Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):717-20. doi: 10.1111/j.1447-0756.2008.00914.x.
Primary leiomyosarcoma of the uterine cervix is an exceedingly rare tumor. Probably, this is first case to be reported in a young woman. A 25-year-old south Indian woman presented with excessive white discharge per vaginum. On examination, a growth in the cervix infiltrating to the anterior vaginal wall was present. Biopsy showed leiomyosarcoma. Two cycles of chemotherapy with cisplatin, doxorubicin and cyclophosphamide were given and then a total hysterectomy with bilateral salpingo-oophorectomy was carried out, followed by local radiation to the anterior vaginal wall. The patient developed extensive metastasis within 6 months of surgery. Because the number of reported cases is very small, the optimal mode of treatment is yet to be established. Additional cases are needed to establish the optimal mode of management and to predict the prognosis.
原发性子宫颈平滑肌肉瘤是一种极为罕见的肿瘤。这可能是首次报道的发生在年轻女性身上的此类病例。一名25岁的南印度女性出现阴道大量白带。检查时发现宫颈有一肿物,已浸润至阴道前壁。活检显示为平滑肌肉瘤。给予顺铂、阿霉素和环磷酰胺进行了两个周期的化疗,然后进行了全子宫切除术及双侧输卵管卵巢切除术,随后对阴道前壁进行了局部放疗。患者在手术后6个月内发生了广泛转移。由于报道的病例数量非常少,最佳治疗方式尚未确立。需要更多病例来确定最佳治疗方案并预测预后。