Leiomyosarcoma of the uterine cervix.

The clinicopathologic features of a patient with uterine leiomyosarcoma arising in the cervix are presented. A 47-year-old Japanese woman was admitted with complaints of hypermenorrhea and abdominal distention. A hysterectomy with bilateral salpingo-oophorectomy revealed a tumor weighing 10.5 kg, which was the largest cervical leiomyosarcoma reported in the literature. She was given eight courses of combination chemotherapy (VADIC and Hydroxyurea, DTIC, Etoposide) and is alive without evidence of recurrence 35 months after the initial therapy.