Byrne James D, Betancourt Tania, Brannon-Peppas Lisa
Department of Biomedical Engineering, The University of Texas at Austin, TX 78738, USA.
Adv Drug Deliv Rev. 2008 Dec 14;60(15):1615-26. doi: 10.1016/j.addr.2008.08.005. Epub 2008 Sep 20.
The objective of this review is to outline current major cancer targets for nanoparticle systems and give insight into the direction of the field. The major targeting strategies that have been used for the delivery of therapeutic or imaging agents to cancer have been broken into three sections. These sections are angiogenesis-associated targeting, targeting to uncontrolled cell proliferation markers, and tumor cell targeting. The targeting schemes explored for many of the reported nanoparticle systems suggest the great potential of targeted delivery to revolutionize cancer treatment.
本综述的目的是概述纳米颗粒系统当前的主要癌症靶点，并深入了解该领域的发展方向。用于将治疗剂或成像剂递送至癌症的主要靶向策略已分为三个部分。这些部分是血管生成相关靶向、针对不受控制的细胞增殖标志物的靶向以及肿瘤细胞靶向。对许多已报道的纳米颗粒系统所探索的靶向方案表明，靶向递送在彻底改变癌症治疗方面具有巨大潜力。
