通过双色荧光原位杂交技术对小家鼠日本亚种（日本）和小家鼠指名亚种（俄罗斯）的核糖体RNA基因位点进行定位。

Mapping of rRNA gene loci in the mice, Mus musculus molossinus (Japan) and Mus musculus musculus (Russia) by double color FISH.

作者信息

Ito Tsuyoshi, Tsuchiya Kimiyuki, Osawa Susumu, Shibata Hideshi, Kanda Naotoshi

机构信息

Laboratory of Veterinary Anatomy, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.

出版信息

J Vet Med Sci. 2008 Sep;70(9):997-1000. doi: 10.1292/jvms.70.997.

DOI:10.1292/jvms.70.997

PMID:18840979

Abstract

Ribosomal RNA gene (rDNA) loci of Russian Mus musculus musculus and of Japanese Mus musuculus molossinus were mapped by double color FISH. The total number of rDNA loci was varied from 5 to 12, although the loci on chromosomes 12, 15, 16, 18, and 19 were common to all mice examined. Instead, polymorphisms of the rDNA loci were found on chromosomes 1, 5, 8, 9, 10, 11, 13 and 17. The novel rDNA loci of M. m. musculus were found in Nov/TUA strain on chromosomes 8 and 17. These observations, together with those of previous reports, suggest that the rDNA loci of Mus musculus species are in the evolutionary process of further translocation to other chromosomes.

摘要

通过双色荧光原位杂交（FISH）对俄罗斯小家鼠指名亚种（Mus musculus musculus）和日本小家鼠琉球亚种（Mus musuculus molossinus）的核糖体RNA基因（rDNA）位点进行了定位。尽管在所有被检查的小鼠中，位于12、15、16、18和19号染色体上的rDNA位点是相同的，但rDNA位点的总数在5到12个之间变化。相反，在1、5、8、9、10、11、13和17号染色体上发现了rDNA位点的多态性。小家鼠指名亚种的新rDNA位点在Nov/TUA品系的8号和17号染色体上被发现。这些观察结果与之前报道的结果一起表明，小家鼠物种的rDNA位点正处于进一步向其他染色体易位的进化过程中。