Uddman R, Sundler F, Emson P
Cell Tissue Res. 1984;237(2):321-7. doi: 10.1007/BF00217151.
Nerve fibres displaying neuropeptide-Y (NPY) immunoreactivity are abundantly distributed in the respiratory tract of cats, guinea-pigs, rats and mice. Fine beaded NPY fibres were seen in whole-mount spreads of the middle-ear mucosa. In the nasal mucosa and in the wall of the Eustachian tube NPY fibres were numerous around arteries and arterioles but sparse in the vicinity of veins; single fibres were found close to the acini of seromucous glands. In the tracheobronchial wall NPY fibres occurred in the proximity of blood vessels, in the subepithelial layer and in the smooth muscle. Surgical and chemical (6-hydroxydopamine treatment) sympathectomy resulted in disappearance of adrenergic and NPY-containing nerve fibres in the nasal mucosa. Sequential staining with antibodies against dopamine-beta-hydroxylase (DBH) and NPY revealed that DBH and NPY occur in the same perivascular nerve fibres in the nasal mucosa. The distribution of NPY fibres in the respiratory tract suggests multiple functions of NPY, such as regulation of local blood flow, glandular secretion and smooth muscle activity.
显示神经肽Y（NPY）免疫反应性的神经纤维大量分布于猫、豚鼠、大鼠和小鼠的呼吸道。在中耳黏膜的整装铺片中可见到纤细的串珠状NPY纤维。在鼻黏膜和咽鼓管壁，NPY纤维在动脉和小动脉周围大量存在，但在静脉附近稀少；在浆液黏液腺腺泡附近可发现单根纤维。在气管支气管壁，NPY纤维出现在血管附近、上皮下层和平滑肌中。手术和化学（6-羟基多巴胺处理）交感神经切除导致鼻黏膜中肾上腺素能和含NPY神经纤维消失。用抗多巴胺-β-羟化酶（DBH）和NPY抗体进行连续染色显示，DBH和NPY存在于鼻黏膜中相同的血管周围神经纤维中。NPY纤维在呼吸道的分布提示NPY具有多种功能，如调节局部血流、腺体分泌和平滑肌活动。
