Lee Dong Young, Seo Eun Hyun, Choo Il Han, Kim Shin Gyeom, Lee Jae Sung, Lee Dong Su, Jhoo Jin Hyeong, Kim Ki Woong, Youn Jong Choul, Woo Jong Inn
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea.
Dement Geriatr Cogn Disord. 2008;26(4):306-13. doi: 10.1159/000161055. Epub 2008 Oct 8.
BACKGROUND/AIM: This study aimed to identify the functional neuroanatomical correlates of impaired clock drawing test (CDT) performance in patients with Alzheimer's disease (AD).
The CDT was administered to 71 patients with AD, and regional cerebral glucose metabolism (rCMglc) was measured by positron emission tomography (PET). Correlations between CDT scores and rCMglc were examined on a voxel-by-voxel basis.
Significant positive correlations were found between CDT performance and rCMglc in the right inferior parietal lobule and right posterior cingulate cortex.
These results provide the first PET evidence that poor CDT performance in patients with AD is closely related to the functional decline in the right hemisphere, especially the right parietal cortex.
背景/目的：本研究旨在确定阿尔茨海默病（AD）患者时钟画测试（CDT）表现受损的功能性神经解剖学关联。
对71例AD患者进行CDT测试，并通过正电子发射断层扫描（PET）测量局部脑葡萄糖代谢（rCMglc）。逐像素检查CDT分数与rCMglc之间的相关性。
在右侧顶下小叶和右侧后扣带回皮质中发现CDT表现与rCMglc之间存在显著正相关。
这些结果提供了首个PET证据，表明AD患者CDT表现不佳与右半球，尤其是右侧顶叶皮质的功能衰退密切相关。
