Department of Geriatrics and Gerontology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.
Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
J Int Neuropsychol Soc. 2023 Feb;29(2):148-158. doi: 10.1017/S1355617722000091. Epub 2022 Feb 21.
To determine whether the DCTclock can detect differences across groups of patients seen in the memory clinic for suspected dementia.
Patients ( = 123) were classified into the following groups: cognitively normal (CN), subtle cognitive impairment (SbCI), amnestic cognitive impairment (aMCI), and mixed/dysexecutive cognitive impairment (mx/dysMCI). Nine outcome variables included a combined command/copy total score and four command and four copy indices measuring drawing efficiency, simple/complex motor operations, information processing speed, and spatial reasoning.
Total combined command/copy score distinguished between groups in all comparisons with medium to large effects. The mx/dysMCI group had the lowest total combined command/copy scores out of all groups. The mx/dysMCI group scored lower than the CN group on all command indices ( < .050, all analyses); and lower than the SbCI group on drawing efficiency ( = .011). The aMCI group scored lower than the CN group on spatial reasoning ( = .019). Smaller effect sizes were obtained for the four copy indices.
These results suggest that DCTclock command/copy parameters can dissociate CN, SbCI, and MCI subtypes. The larger effect sizes for command clock indices suggest these metrics are sensitive in detecting early cognitive decline. Additional research with a larger sample is warranted.
确定 DCTclock 是否能够检测到记忆诊所中疑似痴呆患者的分组差异。
将患者（n=123）分为以下组别：认知正常（CN）、轻度认知障碍（SbCI）、遗忘型认知障碍（aMCI）和混合/执行认知障碍（mx/dysMCI）。九个结果变量包括综合指令/复制总分以及四个指令和四个复制指数，用于评估绘画效率、简单/复杂运动操作、信息处理速度和空间推理能力。
总综合指令/复制得分在所有比较中均能区分不同组别，且具有中到大的效应量。mx/dysMCI 组在所有组别的总分中得分最低。与 CN 组相比，mx/dysMCI 组在所有指令指数上的得分均较低（所有分析，均<0.050），在绘画效率方面的得分低于 SbCI 组（p=0.011）。aMCI 组在空间推理方面的得分低于 CN 组（p=0.019）。四个复制指数的效应量较小。
这些结果表明，DCTclock 的指令/复制参数可以区分 CN、SbCI 和 MCI 亚型。指令时钟指数的较大效应量表明这些指标能够敏感地检测早期认知下降。需要进行更大样本量的进一步研究。
