Hirn-Stadler B, Wbra F, Fowler J F, Rojas A
Clinic for Radiotherapy and Radiobiology, University of Vienna, Austria.
Br J Radiol. 1991 Aug;64(764):740-6. doi: 10.1259/0007-1285-64-764-740.
The acute oesophageal response, after localized mediastinal irradiation in unanaesthetized mice, was assessed with a sequential, non-invasive and clinically orientated assay. Changes in body weight, after single and fractionated X-ray doses (8 fractions in 8 or 15 days and 4 fractions in 4 or 13 days), were recorded and the nadir of weight loss for each regime was used as the end-point. In our studies, quantal and non-quantal analyses of the weight loss data gave good dose-response relationships. The shapes of the dose-effect curves for single doses, 4F/4 days and 8F/8 days showed a remarkable degree of radioresistance, which became less apparent when the overall time was increased to 13 and 15 days for 4 and 8 fractions, respectively. The alpha/beta values (7-17 Gy) are within the range found for other acutely responding normal tissues. Histopathological changes were also assessed and the structural changes observed in the oesophageal epithelium, after a single dose of 34 Gy or after 46 Gy given as 3F/6 days, correlated with the gross changes observed in body weight.
在未麻醉的小鼠中，通过一种连续、非侵入性且以临床为导向的检测方法，评估局部纵隔照射后的急性食管反应。记录单次和分次X射线剂量（8天内8次分次、15天内8次分次以及4天内4次分次、13天内4次分次）后的体重变化，并将每种方案的体重减轻最低点用作终点。在我们的研究中，对体重减轻数据进行的定量和非定量分析得出了良好的剂量反应关系。单次剂量、4次分次/4天和8次分次/8天的剂量效应曲线形状显示出显著程度的放射抗性，当总时间分别增加到4次分次的13天和8次分次的15天时，这种抗性变得不那么明显。α/β值（7 - 17 Gy）在其他急性反应正常组织的范围内。还评估了组织病理学变化，在单次给予34 Gy或3次分次/6天给予46 Gy后，食管上皮中观察到的结构变化与体重的总体变化相关。
