多种序列比对工具的比较。

A comparison of MSA tools.

作者信息

Essoussi Nadia, Boujenfa Khaddouja, Limam Mohamed

机构信息

LARODEC, High Institute of Management, University of Tunis, Tunis, Tunisia.

出版信息

Bioinformation. 2008 Jul 31;2(10):452-5. doi: 10.6026/97320630002452.

DOI:10.6026/97320630002452

PMID:18841241

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2561165/

Abstract

Multiple sequence alignment (MSA) is essential in phylogenetic, evolutionary and functional analysis. Several MSA tools are available in the literature. Here, we use several MSA tools such as ClustalX, Align-m, T-Coffee, SAGA, ProbCons, MAFFT, MUSCLE and DIALIGN to illustrate comparative phylogenetic trees analysis for two datasets. Results show that there is no single MSA tool that consistently outperforms the rest in producing reliable phylogenetic trees.

摘要

多序列比对（MSA）在系统发育、进化和功能分析中至关重要。文献中有多种MSA工具可供使用。在此，我们使用多种MSA工具，如ClustalX、Align-m、T-Coffee、SAGA、ProbCons、MAFFT、MUSCLE和DIALIGN，来阐述针对两个数据集的比较系统发育树分析。结果表明，在生成可靠的系统发育树方面，没有单一的MSA工具始终优于其他工具。