Carlson J N, Glick S D
Department of Pharmacology and Toxicology, Albany Medical College, NY 12208.
Brain Res. 1991 Jun 7;550(2):324-8. doi: 10.1016/0006-8993(91)91335-x.
Rats exposed to stressors that cannot be controlled may develop a deficit in their ability to subsequently learn to control a new stressor. This phenomenon is known as 'learned helplessness' and is a well-accepted animal model of depression. Evidence is presented showing that rats having different directional biases of brain laterality, as indicated in tests of rotational behavior, differ greatly in their response to stressors and to the lack of stressor control. Differences in brain laterality appear to be an important source of variability within the animal model of depression. As with humans, only some rats are vulnerable to depression-like symptoms. These findings are relevant to biological theories of depression that are based upon lateralized specialization of the human brain for affect.
暴露于无法控制的应激源的大鼠，可能会在随后学习控制新应激源的能力上出现缺陷。这种现象被称为“习得性无助”，是一种被广泛接受的抑郁症动物模型。有证据表明，在旋转行为测试中显示出不同大脑偏侧性方向偏好的大鼠，在对应激源以及缺乏应激源控制的反应上存在很大差异。大脑偏侧性的差异似乎是抑郁症动物模型中变异性的一个重要来源。和人类一样，只有一些大鼠易出现类似抑郁症的症状。这些发现与基于人类大脑情感功能侧化特化的抑郁症生物学理论相关。
