Edwards E, Harkins K, Wright G, Henn F
Department of Psychiatry and Behavioral Science, State University of New York, Stony Brook 11794-8101.
Neuropsychopharmacology. 1990 Apr;3(2):109-14.
In the learned helplessness model of depression, naive Sprague-Dawley rats are exposed to a 40-minute uncontrollable shock training and are subsequently tested in a shock escape paradigm. "Helpless rats" exhibit 11 to 15 failures in a 15-trial test while "nonhelpless" rats and naive controls score 0 to 5 failures in the same test. We report on the effect of bilateral adrenalectomy on the induction of learned helplessness. Most of the adrenalectomized rats (70%) became helpless whereas sham controls responded to the training and testing similarly to naive nonoperated rats (20% to 30% helpless). This increase in behavioral deficits after adrenalectomy was reversed by administration of corticosterone, the naturally occurring glucocorticoid in rat. We conclude that secretion from the adrenal cortex is necessary for the incorporation of a learned response after stress and that a dysregulation of the hypothalamic-pituitary-adrenal axis seems to be involved in helpless behavior.
在抑郁症的习得性无助模型中，将未经训练的斯普拉格-道利大鼠暴露于40分钟不可控的电击训练中，随后在电击逃避范式中进行测试。“无助大鼠”在15次试验测试中表现出11至15次失败，而“非无助”大鼠和未经训练的对照大鼠在相同测试中的失败次数为0至5次。我们报告了双侧肾上腺切除术对习得性无助诱导的影响。大多数肾上腺切除的大鼠（70%）变得无助，而假手术对照组对训练和测试的反应与未经手术的未训练大鼠相似（20%至30%无助）。肾上腺切除术后行为缺陷的这种增加通过给予皮质酮（大鼠体内天然存在的糖皮质激素）得以逆转。我们得出结论，肾上腺皮质的分泌对于应激后习得反应的形成是必要的，并且下丘脑-垂体-肾上腺轴的失调似乎与无助行为有关。
