雄性猫尿道的药理学松弛：苯氧苄胺、地西泮、硝苯地平和赛拉嗪的作用研究
Pharmacological relaxation of the urethra in male cats: a study of the effects of phenoxybenzamine, diazepam, nifedipine and xylazine.
作者信息
Mawby D I, Meric S M, Crichlow E C, Papich M G
机构信息
Department of Veterinary Internal Medicine, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon.
出版信息
Can J Vet Res. 1991 Jan;55(1):28-32.
Urethral pressure profiles (UPPs) were recorded in ten adult healthy male cats before and after administration of either phenoxybenzamine, diazepam, nifedipine or xylazine. A significant decrease (p less than 0.05) in urethral pressure at the level of the prostate was observed following treatment with all drugs. Xylazine produced a significant decrease in urethral pressure 4 to 7 cm from the tip of the penis in healthy male cats. None of the drugs used decreased urethral pressure in the zones of pure striated muscle or pure smooth muscle in these cats, making current recommendations for pharmacological management of urethral spasm suspect. Further studies are necessary to evaluate clinical cases of urethral spasm and to study the effects of these drugs on the urethral pressure of cats suffering from this spasm.
在十只成年健康雄性猫身上记录了给予苯氧苄胺、地西泮、硝苯地平或赛拉嗪前后的尿道压力曲线（UPPs）。用所有药物治疗后，在前列腺水平的尿道压力均显著降低（p小于0.05）。赛拉嗪使健康雄性猫阴茎尖端4至7厘米处的尿道压力显著降低。在这些猫中，所使用的药物均未降低纯横纹肌或纯平滑肌区域的尿道压力，这使得目前关于尿道痉挛药物治疗的建议受到质疑。有必要进行进一步研究，以评估尿道痉挛的临床病例，并研究这些药物对患有这种痉挛的猫的尿道压力的影响。
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