Straeter-Knowlen I M, Marks S L, Rishniw M, Speth R C, Wirth W, Knowlen G C
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164, USA.
Am J Vet Res. 1995 Jul;56(7):919-23.
The effects of the skeletal muscle-relaxing drug dantrolene sodium alone, and in combination with the alpha 1-adrenergic antagonist prazosin, on the urethral pressure profile were investigated in male cats with obstructive lower urinary tract disease. Decreases in mean segmental intraurethral pressure induced by dantrolene (n = 3) or dantrolene in combination with prazosin (n = 3) were evaluated statistically, using a paired design. Statistical analysis was applied to absolute (mm of Hg) pressure values. Intravenous administration of dantrolene alone (1 mg/kg of body weight, n = 3) significantly decreased pressure in the postprostatic/penile urethral segment, but did not decrease prostatic urethral pressures. Dantrolene in combination with prazosin (0.03 mg/kg IV) caused a 20% pressure decrease in the prostatic segment (P = 0.060). Preprostatic urethral pressure was not significantly affected by either treatment regimen in the small pool of cats studied. There was no difference in baseline pressures (mm of Hg) in the 3 intraurethral segments of these 6 recently obstructed male cats, compared with historic baseline pressures (mm of Hg) in the 3 intraurethral segments of 28 healthy male cats. These results indicate that dantrolene and prazosin may be effective in relaxing intraurethral skeletal and smooth musculature in male cats clinically afflicted with obstructive lower urinary tract disease. However, it is not certain that administration of muscle relaxants would facilitate urethral catheterization and removal of the obstruction in male cats with blockage of the lower urinary tract. Strikingly, results of this study suggest that urethral muscle spasm had a minor role in these cats.
在患有梗阻性下尿路疾病的雄性猫中，研究了骨骼肌松弛药物丹曲林钠单独使用以及与α1肾上腺素能拮抗剂哌唑嗪联合使用对尿道压力曲线的影响。采用配对设计，对丹曲林（n = 3）或丹曲林与哌唑嗪联合使用（n = 3）引起的平均节段性尿道内压降低进行统计学评估。统计分析应用于绝对（毫米汞柱）压力值。单独静脉注射丹曲林（1毫克/千克体重，n = 3）可显著降低前列腺后/阴茎尿道段的压力，但不会降低前列腺尿道压力。丹曲林与哌唑嗪（0.03毫克/千克静脉注射）联合使用可使前列腺段压力降低20%（P = 0.060）。在所研究的少量猫中，两种治疗方案对前列腺前尿道压力均无显著影响。与28只健康雄性猫的3个尿道内段的历史基线压力（毫米汞柱）相比，这6只近期梗阻的雄性猫的3个尿道内段的基线压力（毫米汞柱）没有差异。这些结果表明，丹曲林和哌唑嗪可能对临床上患有梗阻性下尿路疾病的雄性猫的尿道内骨骼肌和平滑肌有松弛作用。然而，尚不确定给予肌肉松弛剂是否会促进患有下尿路梗阻的雄性猫的尿道插管和梗阻解除。令人惊讶的是，这项研究的结果表明尿道肌肉痉挛在这些猫中作用较小。
