Khanna O P, Gonick P
Urology. 1975 Sep;6(3):323-30. doi: 10.1016/0090-4295(75)90756-6.
The results of our study show that phenoxybenzamine hydrochloride, a potent long-acting alpha-adrenergic blocker, has clearly demonstrable effects on urethral function. In a dose of 0.5 mg. per kilogram of body weight it caused a significant lowering of the resting urethral pressure, a decrease in the arterial pressure, and no change in the intravesical pressure. Higher doses caused similar but more pronounced and prolonged effects. The combined use of phenoxybenzamine and bethanechol increased the intravesical pressure and decreased the urethral pressure. It appears that the predominant mechanism of urethral resistance is alpha-adrenergic activity in smooth muscle. A review of the medical literature, our experimental studies, and limited clinical application lead uo to conclude that phenoxybenzamine could be useful in treating neurogenic vesical dysfunction of various types, urethral syndrome, urgency incontinence, functional outlet obstruction with or without vesicoureteral reflux, drug-related obstructive urinary symptoms, partial prostatic obstruction, and ureteral colic. The combination of phenoxybenzamine and bethanechol could be used in managing patients with atony of the bladder of neuropathic or myopathic origin.
我们的研究结果表明，强效长效α-肾上腺素能阻滞剂盐酸酚苄明对尿道功能有明显的可证实的作用。每公斤体重0.5毫克的剂量会导致静息尿道压力显著降低、动脉压下降，而膀胱内压无变化。更高剂量会产生类似但更显著和持久的效果。酚苄明和氨甲酰甲胆碱联合使用会增加膀胱内压并降低尿道压力。看来尿道阻力的主要机制是平滑肌中的α-肾上腺素能活性。对医学文献、我们的实验研究和有限的临床应用进行回顾后，我们得出结论，酚苄明可用于治疗各种类型的神经源性膀胱功能障碍、尿道综合征、急迫性尿失禁、伴或不伴膀胱输尿管反流的功能性出口梗阻、药物相关的梗阻性尿路症状、部分前列腺梗阻和输尿管绞痛。酚苄明和氨甲酰甲胆碱联合使用可用于治疗神经源性或肌源性膀胱无张力的患者。
