Jubb J S, Lorimer A R, Hawthorne V M, Morgan H G, Lawrie T D
Br Heart J. 1976 Nov;38(11):1189-93. doi: 10.1136/hrt.38.11.1189.
Lipoprotein typing was undertaken in apparently healthy women (419) and men (103) in whom measurements of fasting total cholesterol, triglycerides, and cholesterol content of the major lipoprotein fractions were made. In the female group (30 to 59 years) there was a significant rise in total cholesterol, low density lipoprotein (LDL) cholesterol, and triglycerides with age. Using total cholesterol and triglyceride levels for classification, type II hyperlipoproteinaemia was present in 1 per cent and type IV in 6-7 per cent. When LDL cholesterol levels were also considered, type II occurred in 9-8 per cent ( 8-4% type IIA and 1-4% type IIB). In the male group ( 40 to 59 years) there was no increase in cholesterol or triglyceride levels with age: II per cent had type IV hyperlipoproteinaemia and none had a type II abnormality. When LDL cholesterol levels were also considered, type II occurred in 3 per cent ( 2% type IIA and 1% IIB). The apparent increase in LDL cholesterol frequency of type IIA abnormality in women could be merely the consequence of arbitrary selection of upper limits of normality for LDL cholesterol, but may signify improved detection of a high risk group.
对419名貌似健康的女性和103名貌似健康的男性进行了脂蛋白分型，并测定了他们空腹时的总胆固醇、甘油三酯以及主要脂蛋白组分的胆固醇含量。在女性组（30至59岁）中，总胆固醇、低密度脂蛋白（LDL）胆固醇和甘油三酯水平随年龄显著升高。以总胆固醇和甘油三酯水平进行分类，II型高脂蛋白血症的发生率为1%，IV型为6 - 7%。若同时考虑LDL胆固醇水平，II型的发生率为9 - 8%（IIA型为8 - 4%，IIB型为1 - 4%）。在男性组（40至59岁）中，胆固醇或甘油三酯水平不随年龄增加：2%患有IV型高脂蛋白血症，无人有II型异常。若同时考虑LDL胆固醇水平，II型的发生率为3%（IIA型为2%，IIB型为1%）。女性中IIA型异常的LDL胆固醇频率明显增加，这可能仅仅是任意选择LDL胆固醇正常上限的结果，但也可能意味着对高危人群的检测有所改善。
