Mann J I, Thorogood M
Br Heart J. 1975 Aug;37(8):790-4. doi: 10.1136/hrt.37.8.790.
Fasting serum lipids and lipoprotein patterns were studied in 44 female survivors of acute myocardial infarction under the age of 45 years, and in 84 matched control subjects. Type II hyperlipoproteinaemia was present in 41 per cent of the myocardial infarction patients and in none of the controls. There was, however, no difference in the prevalence of the type IV abnormality, which was present in 7 per cent of the myocardial infarction patients and 8 per cent of the control subjects. Mean cholesterol and triglyceride levels were both significantly higher in the women who had survived myocardial infarction than in the controls; the difference in triglyceride was attributable to the type IIb abnormality which occurred in 11 per cent of these patients. It is suggested that ovarian hormones may protect premenopausal women from type IV hyperlipoproteinaemia and its possible atherogenic sequelae.
对44名年龄在45岁以下的急性心肌梗死女性幸存者以及84名匹配的对照受试者进行了空腹血脂和脂蛋白模式研究。41%的心肌梗死患者存在II型高脂蛋白血症，而对照组无一例出现。然而，IV型异常的患病率在心肌梗死患者和对照受试者中并无差异，分别为7%和8%。心肌梗死存活女性的平均胆固醇和甘油三酯水平均显著高于对照组；甘油三酯的差异归因于11%的此类患者出现的IIb型异常。研究表明，卵巢激素可能使绝经前女性免受IV型高脂蛋白血症及其可能的动脉粥样硬化后遗症的影响。
