Ullrich Roland T, Kracht Lutz W, Jacobs Andreas H
Laboratory for Gene Therapy and Molecular Imaging, Max Planck Institute for Neurological Research with Klaus-Joachim-Zülch-Laboratories, Center for Molecular Medicine, University of Cologne, Gleuelerstrasse 50, Cologne, Germany.
Semin Neurol. 2008 Sep;28(4):484-94. doi: 10.1055/s-0028-1083696. Epub 2008 Oct 8.
Improvements of radionuclide and magnetic resonance-based imaging modalities over the past decade have enabled clinicians to noninvasively assess the dynamics of disease-specific processes at the molecular level in humans. This article will provide an overview of the recent advances in multimodal molecular neuroimaging in patients with primary brain tumors. To date, a range of complementary imaging parameters have been established in the diagnosis of brain tumors. Magnetic resonance imaging (MRI) provides mostly morphological and functional information such as tumor localization, vascular permeability, cell density, and tumor perfusion. The use of positron emission tomography (PET) enables the assessment of molecular processes, such as glucose consumption, expression of nucleoside and amino acid transporters, as well as alterations of DNA and protein synthesis. Taken together, MRI and PET give complementary information about tumor biology and activity, providing an improved understanding about the kinetics of tumor growth.
在过去十年中，基于放射性核素和磁共振的成像技术取得了进步，使临床医生能够在分子水平上对人类疾病特异性过程的动态进行无创评估。本文将概述原发性脑肿瘤患者多模态分子神经成像的最新进展。迄今为止，在脑肿瘤诊断中已经建立了一系列互补的成像参数。磁共振成像（MRI）主要提供形态学和功能信息，如肿瘤定位、血管通透性、细胞密度和肿瘤灌注。正电子发射断层扫描（PET）的应用能够评估分子过程，如葡萄糖消耗、核苷和氨基酸转运体的表达以及DNA和蛋白质合成的改变。MRI和PET结合起来，可提供关于肿瘤生物学和活性的互补信息，有助于更好地理解肿瘤生长动力学。
