Max Planck Insitute for Neurological Research, Cologne, Germany.
J Nucl Med. 2011 Oct;52(10):1585-600. doi: 10.2967/jnumed.110.084210. Epub 2011 Aug 12.
Neuroimaging plays a significant role in the diagnosis of intracranial tumors, especially brain gliomas, and must consist of an assessment of location and extent of the tumor and of its biologic activity. Therefore, morphologic imaging modalities and functional, metabolic, or molecular imaging modalities should be combined for primary diagnosis and for following the course and evaluating therapeutic effects. MRI is the gold standard for providing detailed morphologic information and can supply some additional insights into metabolism (MR spectroscopy) and perfusion (perfusion-weighted imaging) but still has limitations in identifying tumor grade, invasive growth into neighboring tissue, and treatment-induced changes, as well as recurrences. These insights can be obtained by various PET modalities, including imaging of glucose metabolism, amino acid uptake, nucleoside uptake, and hypoxia. Diagnostic accuracy can benefit from coregistration of PET results and MRI, combining the high-resolution morphologic images with the biologic information. These procedures are optimized by the newly developed combination of PET and MRI modalities, permitting the simultaneous assessment of morphologic, functional, metabolic, and molecular information on the human brain.
神经影像学在颅内肿瘤的诊断中起着重要作用，特别是脑胶质瘤，必须包括对肿瘤的位置和范围及其生物学活性的评估。因此，形态成像方式和功能、代谢或分子成像方式应结合起来进行初步诊断，并跟踪病程和评估治疗效果。MRI 是提供详细形态信息的金标准，还可以提供一些关于代谢（磁共振波谱）和灌注（灌注加权成像）的额外见解，但在识别肿瘤分级、向邻近组织浸润生长以及治疗诱导的变化以及复发方面仍然存在局限性。这些见解可以通过各种 PET 方式获得，包括葡萄糖代谢、氨基酸摄取、核苷摄取和缺氧的成像。通过将 PET 结果与 MRI 进行配准，可以将高分辨率形态图像与生物学信息相结合，从而提高诊断准确性。这些程序通过新开发的 PET 和 MRI 方式的组合得到优化，允许同时评估人脑的形态、功能、代谢和分子信息。
