ATreP-Agenzia Provinciale per la Protonterapia, Via F.lli Perini 181, Trento 38122, Italy.
Cancers (Basel). 2012 Mar 7;4(1):257-80. doi: 10.3390/cancers4010257.
Despite the therapeutic advances in neuro-oncology, most patients with glioblastoma ultimately experience local progression/relapse. Re-irradiation has been poorly viewed in the past, mainly due to the overestimated risk of side effects using conventional radiotherapy. To date, thanks to the improvement of several delivery techniques, together with improved imaging capabilities, re-irradiation is a viable salvage treatment option to manage such clinical scenario. A literature overview on the feasibility and efficacy of the different irradiation modalities for recurrent glioblastoma along with considerations on areas of improvement are provided.
尽管神经肿瘤学在治疗上取得了进展,但大多数胶质母细胞瘤患者最终仍会出现局部进展/复发。过去,再放疗的效果不佳,主要是由于传统放疗的副作用风险被高估。迄今为止,由于几种传输技术的改进以及成像能力的提高,再放疗已成为管理此类临床情况的可行挽救治疗选择。本文就复发性胶质母细胞瘤的不同放疗方式的可行性和疗效进行了文献综述,并对需要改进的领域进行了探讨。