Tou Samson, Brown Steven R, Malik Ali I, Nelson Richard L
General Surgery, 18 Bishy-Barnabee Way, Norwich, UK.
Cochrane Database Syst Rev. 2008 Oct 8(4):CD001758. doi: 10.1002/14651858.CD001758.pub2.
Complete rectal prolapse is a life-style altering disability that commonly affects older people. The range of surgical methods available to correct the underlying pelvic floor defects in complete rectal prolapse suggests that there is no agreement about the choice of the best operation.
To determine the effects of surgery on the treatment of rectal prolapse in adults.
We searched the Cochrane Incontinence Group Specialised Register (searched 10 January 2008), the Cochrane Colorectal Cancer Group Trials Register (searched 10 January 2008), CENTRAL (Issue 1, 2008), PubMed (1 January 1950 to 10 January 2008) and EMBASE (1 January 1998 to 10 January 2008). The British Journal of Surgery (January 1995 to January 2008) and the Diseases of the Colon and Rectum (January 1995 to January 2008) were specifically hand searched. The proceedings of the Association of Coloproctology meetings held from 1999 to 2007 were perused. Reference lists of all relevant articles were searched for further trials.
All randomised or quasi-randomised trials of surgery in the management of adult rectal prolapse.
Three reviewers independently selected studies from the literature searches, assessed the methodological quality of eligible trials and extracted data. The four primary outcome measures were: number of patients with recurrent rectal prolapse, number of patients with residual mucosal prolapse, and number of patients with faecal incontinence or constipation.
Twelve randomised controlled trials including 380 participants were identified and included in this review. One trial compared abdominal with perineal approaches to surgery, three trials compared fixation methods, three trials looked at the effects of lateral ligament division, one trial compared techniques of rectosigmoidectomy, two trials compared laparoscopic with open surgery and two trials compared resection with no resection rectopexy.The heterogeneity of the trial objectives, interventions and outcomes made analysis difficult. Many review objectives were covered by only one or two studies with small numbers of participants. With these caveats in mind there is insufficient data to say which of the abdominal and perineal approaches has a better outcome. There were no detectable differences between the methods used for fixation during rectopexy. Division, rather than preservation, of the lateral ligaments was associated with less recurrent prolapse but more post-operative constipation. Laparoscopic rectopexy was associated with fewer post-operative complications and shorter hospital stay than open rectopexy. Bowel resection during rectopexy was associated with lower rates of constipation.
AUTHORS' CONCLUSIONS: The small sample size of included trials together with their methodological weaknesses severely limit the usefulness of this review for guiding practice. It is impossible to identify or refute clinically important differences between the alternative surgical operations. Larger rigorous trials are needed to improve the evidence with which to define optimum surgical treatment for rectal prolapse: the results of one such trial are awaited.
完全性直肠脱垂是一种改变生活方式的残疾,常见于老年人。用于纠正完全性直肠脱垂潜在盆底缺陷的手术方法多样,这表明对于最佳手术选择尚无共识。
确定手术治疗成人直肠脱垂的效果。
我们检索了Cochrane尿失禁组专业注册库(2008年1月10日检索)、Cochrane结直肠癌组试验注册库(2008年1月10日检索)、CENTRAL(2008年第1期)、PubMed(1950年1月1日至2008年1月10日)和EMBASE(1998年1月1日至2008年1月10日)。专门手工检索了《英国外科学杂志》(1995年1月至2008年1月)和《结肠直肠疾病》(1995年1月至2008年1月)。查阅了1999年至2007年举行的结直肠外科学会会议的会议记录。检索了所有相关文章的参考文献列表以查找更多试验。
所有关于成人直肠脱垂手术治疗的随机或半随机试验。
三位评价者独立从文献检索中选择研究,评估合格试验的方法学质量并提取数据。四个主要结局指标为:直肠脱垂复发患者数量、残留黏膜脱垂患者数量、大便失禁或便秘患者数量。
确定了12项随机对照试验,包括380名参与者并纳入本综述。一项试验比较了腹部手术与会阴手术方法,三项试验比较了固定方法,三项试验观察了侧韧带切断的效果,一项试验比较了直肠乙状结肠切除术技术,两项试验比较了腹腔镜手术与开放手术,两项试验比较了直肠固定术的切除与非切除。试验目的、干预措施和结局的异质性使得分析困难。许多综述目的仅由一两项参与者数量较少的研究涉及。考虑到这些注意事项,没有足够的数据表明腹部手术和会阴手术哪种效果更好。直肠固定术中使用的固定方法之间没有可检测到的差异。侧韧带切断而非保留与较少的复发脱垂相关,但术后便秘更多。与开放直肠固定术相比,腹腔镜直肠固定术术后并发症更少,住院时间更短。直肠固定术中进行肠切除与较低的便秘发生率相关。
纳入试验的样本量小及其方法学缺陷严重限制了本综述对指导实践的有用性。无法确定或反驳替代手术操作之间临床上的重要差异。需要更大规模的严谨试验来改善证据,以确定直肠脱垂的最佳手术治疗方法:正在等待一项此类试验的结果。