Amanata Negin, He Li Hong, Swain Michael V, Little David G
Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Westmead, Australia. negin
Med Eng Phys. 2008 Sep;30(7):843-7. doi: 10.1016/j.medengphy.2007.09.008.
Bisphosphonates are commonly used for the treatment of osteoporosis and have recently been shown to increase bone mineral parameters and strength in endochondral fracture repair. There is concern, however, that BPs may negatively affect bone material properties.
Nanoindentation was performed on femoral fracture samples of rats that had undergone closed fracture healing for six weeks to determine hardness and elastic modulus. The rats had received either intravenous saline or a single intravenous dose of zoledronic acid at zero, one or two weeks post fracture (n = 3 per group).
The mean elastic modulus and hardness of mineralised tissue in control calluses were mean 16.4 GPa (S.D. 2.3) and mean 0.65 GPa(S.D. 0.1), respectively. There was no significant change in these parameters with zoledronic acid treatment.
The results from this preliminary data suggest that single dose zoledronic acid treatment in fracture healing may not adversely affect the intrinsic properties of callus bone tissue. Single dose bisphosphonate may be a viable treatment for augmenting fracture repair without negatively affecting the material properties.
双膦酸盐常用于治疗骨质疏松症，最近有研究表明其可增加软骨内骨折修复中的骨矿物质参数和骨强度。然而，人们担心双膦酸盐可能会对骨材料特性产生负面影响。
对经历六周闭合性骨折愈合的大鼠股骨骨折样本进行纳米压痕试验，以确定硬度和弹性模量。这些大鼠在骨折后零周、一周或两周时接受了静脉注射生理盐水或单次静脉注射唑来膦酸（每组n = 3）。
对照骨痂中矿化组织的平均弹性模量和硬度分别为16.4 GPa（标准差2.3）和0.65 GPa（标准差0.1）。唑来膦酸治疗后这些参数无显著变化。
这些初步数据结果表明，骨折愈合过程中单次剂量唑来膦酸治疗可能不会对骨痂骨组织的固有特性产生不利影响。单次剂量双膦酸盐可能是一种可行的治疗方法，可增强骨折修复且不会对材料特性产生负面影响。
