Baumann Ulrich
Immunological Unit, Department of Pediatric Pulmonology and Neonatology, Hanover Medical School, Carl-Neuberg-Str., 30625 Hannover, Germany.
Expert Rev Vaccines. 2008 Oct;7(8):1257-76. doi: 10.1586/14760584.7.8.1257.
Mucosal vaccination offers attractive advantages to conventional systemic vaccination, such as higher levels of antibodies and protection at the airway surface. This review gives an overview of recent experimental and clinical data on nasal, oral and sublingual vaccines against bacterial respiratory pathogens, such as Streptococcus pneumoniae , Haemophilus influenzae , Neisseria meningitidis , Moraxella catarrhalis , Bordetella pertussis , Pseudomonas aeruginosa and Mycobacterium tuberculosis . Subsequently, we discuss further vaccine development that opens the focus to clinical use.
黏膜疫苗与传统的全身疫苗相比具有显著优势，例如能产生更高水平的抗体并在气道表面提供保护。本综述概述了近期针对细菌性呼吸道病原体（如肺炎链球菌、流感嗜血杆菌、脑膜炎奈瑟菌、卡他莫拉菌、百日咳博德特菌、铜绿假单胞菌和结核分枝杆菌）的鼻用、口服和舌下疫苗的实验及临床数据。随后，我们讨论了进一步的疫苗研发情况，这些研发将重点转向临床应用。
