Mariani C, Bresolin N, Farina E, Moggio M, Ferrante C, Ciafaloni E, Sertorelli S, Ciccone A, Scarlato G
Department of Neurology, Medical School, University of Milan, Italy.
Clin Neuropathol. 1991 Jul-Aug;10(4):171-6.
Recent evidences of a predisposing genetic factor associated with Alzheimer's disease (DAT) suggests that important alterations may be expressed in tissues other than the brain. We present morphological and biochemical studies on muscle obtained from ten patients with Alzheimer's disease and coeval controls. Muscle biopsy examination showed an increased subsarcolemmal mitochondrial oxidative activity in three patients. The biochemical studies showed an increased oxidative enzyme activity only in the DAT group. The CoQ10 level, studied so far in three DAT patients, was greatly reduced (approximately 50%) compared with controls. Possible new peripheral markers in Alzheimer's disease will be discussed.
近期与阿尔茨海默病（DAT）相关的遗传易感性因素的证据表明，重要的改变可能在大脑以外的组织中表现出来。我们对10例阿尔茨海默病患者及同期对照者的肌肉进行了形态学和生化研究。肌肉活检检查显示，3例患者肌膜下线粒体氧化活性增加。生化研究表明，仅在DAT组氧化酶活性增加。到目前为止，在3例DAT患者中进行的辅酶Q10水平研究显示，与对照组相比大幅降低（约50%）。将讨论阿尔茨海默病可能的新的外周标志物。
