Sims N R, Blass J P, Murphy C, Bowen D M, Neary D
Ann Neurol. 1987 May;21(5):509-10. doi: 10.1002/ana.410210517.
The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.
磷酸果糖激酶是糖酵解的一种关键调节酶，对6例原发性退行性痴呆患者（包括4例阿尔茨海默病患者）的新皮质神经外科样本测定了该酶的活性。与非痴呆对照样本相比，未发现一致的活性降低情况。这些结果与先前报道的阿尔茨海默病患者死后脑标本活性大幅降低形成对比。
