Mackenzie J M
Neuropathology Laboratory, Walton Hospital, Liverpool, UK.
Clin Neuropathol. 1991 Jul-Aug;10(4):187-9.
The circle of Willis is known to exhibit considerable anatomical variability. The incidence of variations of the circle is said to be greater when an aneurysm is present, particularly one of the anterior communicating artery. In this study 40 circles of Willis bearing 51 saccular aneurysms were dissected and examined macroscopically. Forty circles from patients with other neurological diseases served as controls. Ninety-seven per cent of circles bearing aneurysms showed variations from a hypothetical "normal" structure, as did 85% of controls. The aneurysm group as a whole, and circles bearing anterior communicating aneurysms, showed a higher incidence of anterior cerebral artery asymmetry than controls (p less than 0.001), as did the latter when compared with circles bearing aneurysms at other sites (p less than 0.01), but there were no other significant differences.
已知 Willis 环存在相当大的解剖变异。据说当存在动脉瘤时，尤其是前交通动脉的动脉瘤，该环的变异发生率更高。在本研究中，对带有51个囊状动脉瘤的40个 Willis 环进行了解剖并进行宏观检查。来自其他神经系统疾病患者的40个环作为对照。带有动脉瘤的环中有97%显示出与假设的“正常”结构存在差异，对照组的这一比例为85%。整个动脉瘤组以及带有前交通动脉瘤的环，其大脑前动脉不对称的发生率高于对照组（p<0.001），对照组与其他部位带有动脉瘤的环相比也是如此（p<0.01），但没有其他显著差异。
