• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Three-class-resistant human immunodeficiency virus type 1 variant in a drug-naive heterosexual couple.一对未接受过抗逆转录病毒治疗的异性恋伴侣中出现的对三类药物耐药的1型人类免疫缺陷病毒变体。
J Clin Microbiol. 2008 Nov;46(11):3856-9. doi: 10.1128/JCM.01122-08. Epub 2008 Sep 24.
2
Both human immunodeficiency virus cellular DNA sequencing and plasma RNA sequencing are useful for detection of drug resistance mutations in blood samples from antiretroviral-drug-naive patients.人类免疫缺陷病毒细胞DNA测序和血浆RNA测序对于检测初治抗逆转录病毒药物患者血样中的耐药性突变均有用。
J Clin Microbiol. 2007 Jun;45(6):1783-8. doi: 10.1128/JCM.00056-07. Epub 2007 Apr 18.
3
Detection of a drug-resistant human immunodeficiency virus variant in a newly infected heterosexual couple.
Clin Infect Dis. 2002 Jan 1;34(1):116-7. doi: 10.1086/322521.
4
Selection of drug-resistant HIV-1 during the early phase of viral decay is uncommon in treatment-naïve patients initiated on a three- or four-drug antiretroviral regimen including lamivudine.在开始接受包括拉米夫定在内的三药或四药抗逆转录病毒治疗方案的初治患者中，病毒衰减早期出现耐药性HIV-1的情况并不常见。
J Med Virol. 2009 Jan;81(1):1-8. doi: 10.1002/jmv.21363.
5
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.在未经抗逆转录病毒治疗的慢性HIV感染患者中，低丰度耐药病毒变体对治疗结果有显著影响。
J Infect Dis. 2009 Mar 1;199(5):693-701. doi: 10.1086/596736.
6
Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population.耐药性人类免疫缺陷病毒的传播适应性及抗逆转录病毒治疗人群中的耐药流行情况。
J Infect Dis. 2003 Feb 15;187(4):683-6. doi: 10.1086/367989. Epub 2003 Jan 29.
7
Evolution and predictors of HIV type-1 drug resistance in patients failing combination antiretroviral therapy in Italy.意大利接受联合抗逆转录病毒治疗失败患者中HIV-1耐药性的演变及预测因素
Antivir Ther. 2009;14(3):359-69.
8
High frequency of antiretroviral drug resistance among HIV-infected adults receiving first-line highly active antiretroviral therapy in N'Djamena, Chad.在乍得恩贾梅纳接受一线高效抗逆转录病毒治疗的艾滋病毒感染成人中，抗逆转录病毒药物耐药性的高发生率。
Clin Infect Dis. 2009 Jul 1;49(1):155-9. doi: 10.1086/599611.
9
Changing transmission fitness of drug-resistant human immunodeficiency virus against a background of evolving antiretroviral therapy.在不断发展的抗逆转录病毒疗法背景下，耐药性人类免疫缺陷病毒传播适应性的变化
J Infect Dis. 2003 Oct 15;188(8):1258; author reply 1258-9. doi: 10.1086/378679.
10
Antiretroviral recommendations may influence the rate of transmission of drug-resistant HIV type 1.抗逆转录病毒治疗建议可能会影响耐药性1型艾滋病毒的传播率。
Clin Infect Dis. 2005 Jul 15;41(2):227-32. doi: 10.1086/431203. Epub 2005 May 31.

引用本文的文献

1
A novel methodology for large-scale phylogeny partition.一种大规模系统发育分区的新方法。
Nat Commun. 2011;2:321. doi: 10.1038/ncomms1325. Epub 2011 May 24.

本文引用的文献

1
Update of the drug resistance mutations in HIV-1: Spring 2008.2008年春季HIV-1耐药性突变的更新情况。
Top HIV Med. 2008 Apr-May;16(1):62-8. doi: 10.1007/s11750-007-0034-z.
2
Evidence of dual sexual transmission of multi-resistant HIV with two years persistence of resistance to NRTI and NNRTI: a case report.具有对核苷类逆转录酶抑制剂（NRTI）和非核苷类逆转录酶抑制剂（NNRTI）持续两年耐药性的多重耐药艾滋病毒双性传播证据：一例报告
Infection. 2008 Mar;36(2):178-80. doi: 10.1007/s15010-007-6293-7. Epub 2007 Oct 25.
3
High rates of forward transmission events after acute/early HIV-1 infection.急性/早期HIV-1感染后较高的病毒传播率。
J Infect Dis. 2007 Apr 1;195(7):951-9. doi: 10.1086/512088. Epub 2007 Feb 16.
4
Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease.药物和HLA I类限制性免疫反应对人类免疫缺陷病毒1型蛋白酶的双重选择压力
J Virol. 2007 Mar;81(6):2887-98. doi: 10.1128/JVI.01547-06. Epub 2007 Jan 3.
5
Epidemiology of antiretroviral drug resistance in drug-naïve persons.初治患者抗逆转录病毒药物耐药性的流行病学
Curr Opin Infect Dis. 2007 Feb;20(1):22-32. doi: 10.1097/QCO.0b013e328013caff.
6
HIV-1 reverse transcriptase mutants resistant to nonnucleoside reverse transcriptase inhibitors do not adversely affect DNA synthesis: pre-steady-state and steady-state kinetic studies.对非核苷类逆转录酶抑制剂耐药的HIV-1逆转录酶突变体不会对DNA合成产生不利影响：预稳态和稳态动力学研究。
J Acquir Immune Defic Syndr. 2006 Aug 1;42(4):405-11. doi: 10.1097/01.qai.0000222288.90201.33.
7
Multiple drug class-wide resistance associated with poorer survival after treatment failure in a cohort of HIV-infected patients.在一组HIV感染患者中，多种药物类别广泛耐药与治疗失败后较差的生存率相关。
AIDS. 2005 Jul 1;19(10):1081-9. doi: 10.1097/01.aids.0000174455.01369.ad.
8
Evolution of phenotypic drug susceptibility and viral replication capacity during long-term virologic failure of protease inhibitor therapy in human immunodeficiency virus-infected adults.人类免疫缺陷病毒感染成人接受蛋白酶抑制剂治疗长期病毒学失败期间表型药物敏感性和病毒复制能力的演变
J Virol. 2002 Nov;76(21):11104-12. doi: 10.1128/jvi.76.21.11104-11112.2002.
9
Performance of an in-house genotypic antiretroviral resistance assay in patients pretreated with multiple human immunodeficiency virus type 1 protease and reverse transcriptase inhibitors.在接受多种1型人类免疫缺陷病毒蛋白酶和逆转录酶抑制剂预处理的患者中进行内部基因型抗逆转录病毒耐药性检测的表现。
J Clin Virol. 2002 Jul;25(1):57-62. doi: 10.1016/s1386-6532(01)00252-9.
10
Detection of a drug-resistant human immunodeficiency virus variant in a newly infected heterosexual couple.
Clin Infect Dis. 2002 Jan 1;34(1):116-7. doi: 10.1086/322521.

一对未接受过抗逆转录病毒治疗的异性恋伴侣中出现的对三类药物耐药的1型人类免疫缺陷病毒变体。

Three-class-resistant human immunodeficiency virus type 1 variant in a drug-naive heterosexual couple.

作者信息

Razzolini Francesca, Saladini Francesco, Malincarne Lisa, Vicenti Ilaria, Palladino Nicola, Romano Laura, Francisci Daniela, Zazzi Maurizio

机构信息

Section of Microbiology, Department of Molecular Biology, University of Siena, Viale Bracci 1, I-53100 Siena, Italy.

出版信息

J Clin Microbiol. 2008 Nov;46(11):3856-9. doi: 10.1128/JCM.01122-08. Epub 2008 Sep 24.

DOI:10.1128/JCM.01122-08
PMID:18845824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2576576/
Abstract

Combination antiretroviral treatment was initiated in a heterosexual couple newly diagnosed with human immunodeficiency virus type 1 infection. Multiple genotypic drug resistance testing following early rebound of viral load revealed that the same three-class-resistant human immunodeficiency virus type 1 strain had been present in both patients since before initiation of treatment.

摘要

对一对新诊断为1型人类免疫缺陷病毒感染的异性恋夫妇开始了联合抗逆转录病毒治疗。病毒载量早期反弹后的多次基因型耐药性检测显示，自治疗开始前，两名患者体内就已存在相同的对三类药物耐药的1型人类免疫缺陷病毒毒株。