Li Yufeng, Li Yuan, Lai Qiaohong, Zhang Hanwang, Zhu Guijin, Jin Lei, Yue Jing
Department of Obstetrics, Tongji Hospital, Tongji Medical College, Huzhong University of Science and Technology, Wuhan 430030, China.
J Huazhong Univ Sci Technolog Med Sci. 2008 Oct;28(5):618-20. doi: 10.1007/s11596-008-0529-3. Epub 2008 Oct 10.
In order to compare GnRH agonist with antagonist protocol for the same patient during controlled ovarian stimulation cycles, the in vitro fertilization and embryo transfer (IVF-ET) outcome was retrospectively studied in 81 patients undergoing 105 agonist protocols and 88 antagonist protocols. The results showed that there was no statistically significant difference in duration of ovarian stimulation, number of ampoules, oocytes retrieved, serum estradiol (E(2)) and progesterone (P) levels, thickness of endometrium, the zygote-and blastocyst-development rate between GnRH agonist and antagonist protocols (P>0.05). High quality embryo rate was higher in antagonist protocols, but there was no significant difference between two protocols. Implantation rate and clinical pregnant rate were significantly higher in antagonist protocol (15.82% and 30.26%, respectively) than in agonist protocol (5.26% and 10.64% respectively (P<0.05). It was concluded GnRH antagonist protocol probably improved the outcome of pregnancy of older patients with a history of multiple failure of IVF-ET in a GnRH protocol.
为了在控制性卵巢刺激周期中对同一患者的促性腺激素释放激素（GnRH）激动剂方案和拮抗剂方案进行比较，回顾性研究了81例患者的体外受精-胚胎移植（IVF-ET）结局，这些患者接受了105个激动剂方案和88个拮抗剂方案。结果显示，GnRH激动剂方案和拮抗剂方案在卵巢刺激持续时间、安瓿数量、回收的卵母细胞数量、血清雌二醇（E₂）和孕酮（P）水平、子宫内膜厚度、合子和囊胚发育率方面无统计学显著差异（P>0.05）。拮抗剂方案的优质胚胎率更高，但两种方案之间无显著差异。拮抗剂方案的着床率和临床妊娠率（分别为15.82%和30.26%）显著高于激动剂方案（分别为5.26%和10.64%，P<0.05）。结论是，GnRH拮抗剂方案可能改善了既往在GnRH方案中多次IVF-ET失败的老年患者的妊娠结局。
