Maurya Pawan Kumar, Rizvi Syed Ibrahim
Department of Biochemistry, University of Allahabad, Allahabad, India.
Nat Prod Res. 2009;23(12):1072-9. doi: 10.1080/14786410802267643.
Antioxidant effect of tea catechins has been shown in many epidemiological studies. In the present study we report the protective mechanism of tea catechins (EGCG, ECG, EGC, EC) on various oxidative stress parameters, which are elevated during aging in humans. We hereby report the in vitro effect of tea catechins on erythrocyte malondialdehyde (MDA), reduced glutathione (GSH), and on membrane sulphydryl (-SH) group in humans. Results show an age-dependent increase in erythrocyte MDA level and a decrease in GSH and membrane-SH group concentration. We report that tea catechins show significant protection to erythrocyte against oxidative stress induced by tert-butyl hydroperoxide (t-BHP). The effect was more pronounced in older age group compared to lower age group. The findings suggest a possible role of tea catechins as anti-aging compounds.
许多流行病学研究已表明茶儿茶素具有抗氧化作用。在本研究中，我们报告了茶儿茶素（表没食子儿茶素没食子酸酯、表儿茶素没食子酸酯、表儿茶素、儿茶素）对人体衰老过程中升高的各种氧化应激参数的保护机制。在此，我们报告茶儿茶素对人体红细胞丙二醛（MDA）、还原型谷胱甘肽（GSH）和膜巯基（-SH）基团的体外作用。结果显示，红细胞MDA水平随年龄增长而升高，GSH和膜-SH基团浓度则降低。我们报告称，茶儿茶素对叔丁基过氧化氢（t-BHP）诱导的红细胞氧化应激具有显著保护作用。与低年龄组相比，该作用在高年龄组中更为明显。这些发现表明茶儿茶素可能具有抗衰老化合物的作用。
